| Description: |
Lycopus uniflorus, commonly known as bugleweed, is usually found near freshwater wetland and has a wide abundance in Lebanon. The plant has some folk use for treatment of gastrointestinal disorders and reduction of inflammation. No studies were conducted on Lycopus uniflorus, but other species were reported to possess anti-allergic [1], anti-inflammatory [2], antihyperthyroidism [3], Yarnell and Abascal, 2006 E. Yarnell and K. Abascal, Botanical medicine for thyroid regulation, Alternative and Complementary Therapies (2006), pp. 107–112. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (2) antioxidant [4] and anticancer [5] activities. The present study was conducted to investigate the potential role of L. uniflorus water extract on inflammation and gastric ulcer in rat model. Pretreatment with the extract (50, 100 and 200mg/kg BW by gastric gavage) produced a dose dependent protection against gastric ulcer induced by 60% ethanol. Results showed that 50mg/kg and 100mg/kg caused 20.87 and 80.10%, respectively, compared to 41.70% for cimetidine at 11.5mg/kg BW dose. The same doses were used to test for anti-inflammatory activity against edema induced in hind paw by carrageenan. Intra-peritoneal doses of 100 and 200mg/kg BW of the extract showed significant (p |