| Title: |
VANTAGE: van-based real-time HIV sequencing for transmission mapping and drug resistance profiling in war-affected Ukraine |
| Authors: |
Kovalenko, Ganna; Liulchuk, Mariia G; Filippovych, Myroslava; Smyrnov, Pavlo; Strathdee, Steffanie A; Vasylyeva, Tetyana I |
| Source: |
AIDS, vol 40, iss 1 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2026 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3207 Medical Microbiology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); HIV/AIDS (rcdc); Genetics (rcdc); Infectious Diseases (rcdc); Antimicrobial Resistance (rcdc); Humans (mesh); Ukraine (mesh); HIV Infections (mesh); HIV-1 (mesh); Drug Resistance; Viral (mesh); pol Gene Products; Human Immunodeficiency Virus (mesh); Sequence Analysis; DNA (mesh); Genotype (mesh); Molecular Epidemiology (mesh); Phylogeny (mesh); Mobile Health Units (mesh); Male (mesh) |
| Subject Geographic: |
123 - 126 |
| Description: |
We deployed the VANTAGE (VAN for Transmissible Agent Genomic Epidemiology) mobile system in Lviv, Ukraine, demonstrating end-to-end sequencing of dried blood spot samples within a clinic van usually serving de-occupied and frontline regions. HIV-1 pol sequences were obtained from 50% of samples, all subtype A6. Median time to 100× coverage was 38 min. Phylogenetic analysis revealed a local transmission cluster including a displaced person and the non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation E138A, supporting real-time HIV genomic surveillance in humanitarian crises. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt8tb3r05z; https://escholarship.org/uc/item/8tb3r05z; https://escholarship.org/content/qt8tb3r05z/qt8tb3r05z.pdf |
| DOI: |
10.1097/qad.0000000000004360 |
| Availability: |
https://escholarship.org/uc/item/8tb3r05z; https://escholarship.org/content/qt8tb3r05z/qt8tb3r05z.pdf; https://doi.org/10.1097/qad.0000000000004360 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.38F86107 |
| Database: |
BASE |