Novel movable typing for personalized Vein-Chips in large scale:recapitulate patient-specific Virchow's triad and its contribution to cerebral venous sinus thrombosis
| Title: | Novel movable typing for personalized Vein-Chips in large scale:recapitulate patient-specific Virchow's triad and its contribution to cerebral venous sinus thrombosis |
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| Authors: | Zhao, Yunduo Charles; Zhang, Yingqi; Wang, Zihao; Jiang, Fengtao; Kyanian, Kiarash; Aye, San-Seint-Seint; Hong, Tianbo; Vatankhah, Parham; Nasser, Arian; Sun, Allan; Moldovan, Laura; Su, Qian P.; Cho, Ann-Na; Wang, Yao; Passam, Freda; Ang, Timothy; Ju, Lining Arnold |
| Source: | Zhao, Y C, Zhang, Y, Wang, Z, Jiang, F, Kyanian, K, Aye, S-S-S, Hong, T, Vatankhah, P, Nasser, A, Sun, A, Moldovan, L, Su, Q P, Cho, A-N, Wang, Y, Passam, F, Ang, T & Ju, L A 2023, 'Novel movable typing for personalized Vein-Chips in large scale : recapitulate patient-specific Virchow's triad and its contribution to cerebral venous sinus thrombosis', Advanced Functional Materials, vol. 33, no. 23, 2214179, pp. 1-13. https://doi.org/10.1002/adfm.202214179 |
| Publication Year: | 2023 |
| Subject Terms: | biofabrications; fibrin; mechanobiology; organ on chips; shear stress; strokes; thrombosis |
| Description: | The Vein-Chip recapitulates CVST Virchow's triad and enables systematic characterization of venous thrombogenesis with respect to fibrin formation and platelet aggregation. Distinct from the arterial setting, platelets universally adhere across the entire CVS Vein-Chip independent of stenotic geometry and flow disturbance. Intriguingly, fibrin propagates along with the flow direction, but exclusively deposits to the inner vessel wall. Upon inflammatory endothelial injury, fibrin deposition mirrors to the outer vessel wall, but still not in the lumen. Together, the Vein-Chip promises future applications for personalized thrombotic assessment and monitoring. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1616-301X; 1616-3028 |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/000958501900001; info:eu-repo/semantics/altIdentifier/pissn/1616-301X; info:eu-repo/semantics/altIdentifier/eissn/1616-3028 |
| DOI: | 10.1002/adfm.202214179 |
| Availability: | https://researchers.mq.edu.au/en/publications/9f182745-8dfa-47f1-9133-43fa4a897ee4; https://doi.org/10.1002/adfm.202214179; https://research-management.mq.edu.au/ws/files/343730597/Publisher_version_open_access_.pdf; https://www.scopus.com/pages/publications/85151444831 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.38F9CD1A |
| Database: | BASE |