| Title: |
The effect of short-term amiodarone treatment on the effectiveness of catheter ablation in patients with persistent atrial fibrillation refractory to cardioversion |
| Authors: |
Pytkowski, Mariusz; Ciszewski, Jan; Erhenhalt, Grzegorz; Farkowski, Michał M; Baranowski, Rafał; Rymuza, Hanna; Jędrzejczyk, Barbara; Jankowska, Agnieszka; Kowalik, Ilona; Syska, Paweł; Lewandowski, Michał; Kołakowski, Karol; Zalewska, Joanna; Sterliński, Maciej; Maciąg, Aleksander |
| Source: |
Polish Heart Journal (Kardiologia Polska); Vol 83, No 10 (2025); 1152-1159 |
| Publisher Information: |
Polish Cardiac Society |
| Publication Year: |
2025 |
| Collection: |
Via Medica Journals |
| Subject Terms: |
amiodarone; cardioversion refractory atrial fibrillation; catheter ablation; electrical cardioversion; persistent atrial fibrillation |
| Description: |
Background: Little is known about the effect of amiodarone therapy in patients with persistent atrial fibrillation refractory to electrical cardioversion (AF-REC) scheduled for catheter ablation (CA).Aims: This study aimed to determine whether postulated atrial reverse remodeling achieved through short-term pre- and post-ablation amiodarone therapy with sinus rhythm restoration prior to CA affects the long-term effectiveness of the rhythm control strategy in AF-REC patients.Material and methods: AF-REC patients scheduled for CA were included in this retrospective study. In patients who received amiodarone (group A), sinus rhythm was restored before CA. In patients without amiodarone (group NA), sinus rhythm was restored at the end of CA. Results of outpatient visits, 72-hour Holter electrocardiography, echocardiography, and perceived symptoms were assessed in follow-up.Results: The study population included 56 patients: 37 from group A and 19 group NA. A median follow-up was 39.5 months. The primary endpoint (AF-free survival) was achieved in 17 (45.9%) patients in group A and in 3 (15.8%) patients in group NA (P = 0.026). Secondary endpoint, conversion of AF from persistent to paroxysmal or no AF was achieved in 32 patients (86.5%) from group A and 9 patients (47.4%) from group NA (odds ratio 8.0; 95% confidence interval, 2.1–30.0; P = 0.002). Age-adjusted left ventricular ejection fraction improvement was greater in group A in comparison to group NA (P = 0.004). Patient’s symptoms (European Heart Rhythm Association scale) improved in both groups A and NA (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://journals.viamedica.pl/polish_heart_journal/article/view/107768 |
| DOI: |
10.33963/v.phj.107768 |
| Availability: |
https://journals.viamedica.pl/polish_heart_journal/article/view/107768; https://doi.org/10.33963/v.phj.107768 |
| Rights: |
The copyright to the submitted manuscript is held by the Author, who grants the Polish Cardiac Society a nonexclusive licence to use, reproduce, and distribute the work, including for commercial purposes. Polish Heart Journal (Kardiologia Polska) is an open access journal that applies the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (CC BY-NC-ND 4.0), allowing third parties to download articles and share them with others, provided the original work is properly cited, not changed in any way, distributed under the same licence, and used for non-commercial purposes only. For commercial use, please contact the journal office: polishheartjournal@ptkardio.pl. If submitted work has been funded by institutional grant, the applicant may optionally choose to release the work under Creative Commons licence: attribution (CC BY) to meet the requirements of funding party, if applicable. Licence Terms can be downloaded here. ; Przesyłając manuskrypt wraz z ilustracjami i tabelami, automatycznie i nieodpłatnie przenosi (przenoszą) na Polskie Towarzystwo Kardiologiczne wszelkie prawa autorskie do wydawania oraz rozpowszechniania nadesłanych materiałów we wszystkich znanych formach i na wszystkich znanych polach eksploatacji, bez ograniczeń terytorialnych językowych pod warunkiem, że materiały te zostaną zaakceptowane do publikacji. |
| Accession Number: |
edsbas.393A5370 |
| Database: |
BASE |