| Title: |
Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial |
| Authors: |
Aker, Karoline; Thomas, Niranjan; Adde, Lars; Koshy, Beena; Martinez-Biarge, Miriam; Nakken, Ingeborg; Padankatti, Caroline S; Støen, Ragnhild |
| Contributors: |
The Joint Research Committee between St. Olavs Hospital, Trondheim University Hospital, and the Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway; The Liaison Committee for Education, Research and Innovation in Central Norway |
| Source: |
Archives of Disease in Childhood - Fetal and Neonatal Edition ; volume 107, issue 1, page 32-38 ; ISSN 1359-2998 1468-2052 |
| Publisher Information: |
BMJ |
| Publication Year: |
2021 |
| Description: |
Objective To evaluate the accuracy of neonatal MRI and general movements assessment (GMA) in predicting neurodevelopmental outcomes in infants with hypoxic-ischaemic encephalopathy (HIE). Design Secondary analyses of a randomised controlled trial (RCT). Setting Tertiary neonatal intensive care unit in India. Methods Fifty infants with HIE were included in an RCT of therapeutic hypothermia (25 cooled and 25 non-cooled). All infants underwent brain MRI at day 5, GMA at 10–15 weeks and outcome assessments including Bayley Scales of Infant and Toddler Development, third edition, at 18 months. Associations between patterns of brain injury, presence/absence of fidgety movements (FMs) and outcomes were assessed. Results Seventeen of 47 (36%) had adverse outcome (5 (21%) cooled vs 12 (52%) non-cooled, p=0.025). Eight infants died (four before an MRI, another three before GMA). Two developed severe cerebral palsy and seven had Bayley-III motor/cognitive composite score |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/archdischild-2020-321309 |
| Availability: |
https://doi.org/10.1136/archdischild-2020-321309; https://syndication.highwire.org/content/doi/10.1136/archdischild-2020-321309 |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.3944BB7C |
| Database: |
BASE |