| Title: |
Exploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries ; ENEngelskEnglishExploring the cost-effectiveness of high versus low perioperative fraction of inspired oxygen in the prevention of surgical site infections among abdominal surgery patients in three low- and middle-income countries |
| Authors: |
Kachapila, Mwayi; Monahan, Mark; Ademuyiwa, Adesoji O.; Adinoyi, Yakubu Momohsani; Biccard, Bruce M.; George, Christina; Ghosh, Dhruva N.; Glasbey, James; Morton, Dion G.; Osayomwanbo, Osaheni; Pearse, Rupert; Roberts, Tracy E.; Suroy, Atul; Yakubu, Saidu Yusuf; Oppong, Raymond; Aguilera, Maria Lorena; Alexander, Philip; Ingabire, J.C. Allen; Ismaïl, Lawani; Salem, Hosni Khairy; Teddy Kojo, Anyomih Theophilus; Lapitan, Marie Carmela; Mutabazi, Alphonse Zeta; Nepogodiev, Dmitri; Pata, Francesco; Qureshi, Ahmad Uzair; Ramos-De la Medina, Antonio; Rayne, Sarah; Søreide, Kjetil; Veen, Torhild; Kanani, Arezo; Styles, Kristian; Herikstad, Ragnar; Larsen, Johannes Wiik; Søreide, Jon Arne; Jensen, Elisabeth; Gran, Mads; Aahlin, Eirik Kjus; Gaarder, Tina; Monrad-Hansen, Peter Wiel; Næss, Pål Aksel; Lauzikas, Giedrius; Wiborg, Joachim; Holte, Silje Stensholt; Augestad, Knut Magne; Singh, Banipal Gurpreet; Monteleone, Michela; Moe, Thomas Tetens; Schultz, Johannes Kurt; Bliksøen, Marte; NIHR Global Health Research Unit on Global Surgery; GlobalSurg Collaborative |
| Source: |
2772-6096. |
| Publication Year: |
2024 |
| Collection: |
Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| Description: |
Background This study assessed the potential cost-effectiveness of high (80–100%) vs low (21–35%) fraction of inspired oxygen (FiO2) at preventing surgical site infections (SSIs) after abdominal surgery in Nigeria, India, and South Africa. Methods Decision-analytic models were constructed using best available evidence sourced from unbundled data of an ongoing pilot trial assessing the effectiveness of high FiO2, published literature, and a cost survey in Nigeria, India, and South Africa. Effectiveness was measured as percentage of SSIs at 30 days after surgery, a healthcare perspective was adopted, and costs were reported in US dollars ($). Results High FiO2 may be cost-effective (cheaper and effective). In Nigeria, the average cost for high FiO2 was $216 compared with $222 for low FiO2 leading to a −$6 (95% confidence interval [CI]: −$13 to −$1) difference in costs. In India, the average cost for high FiO2 was $184 compared with $195 for low FiO2 leading to a −$11 (95% CI: −$15 to −$6) difference in costs. In South Africa, the average cost for high FiO2 was $1164 compared with $1257 for low FiO2 leading to a −$93 (95% CI: −$132 to −$65) difference in costs. The high FiO2 arm had few SSIs, 7.33% compared with 8.38% for low FiO2, leading to a −1.05 (95% CI: −1.14 to −0.90) percentage point reduction in SSIs. Conclusion High FiO2 could be cost-effective at preventing SSIs in the three countries but further data from large clinical trials are required to confirm this. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://hdl.handle.net/10852/107193; 2227372; BJA Open; https://doi.org/10.1016/j.bjao.2023.100207 |
| DOI: |
10.1016/j.bjao.2023.100207 |
| Availability: |
http://hdl.handle.net/10852/107193; https://doi.org/10.1016/j.bjao.2023.100207 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.398985D6 |
| Database: |
BASE |