| Title: |
Alliacane-Type Secondary Metabolites from Submerged Cultures of the Basidiomycete Clitocybe nebularis |
| Authors: |
Schrey, Hedda; Scheele, Tarek; Ulonska, Conrad; Nedder, Dana Leoni; Neudecker, Tim; Spiteller, Peter; Stadler, Marc |
| Publisher Information: |
American chemical society; Universität Bremen; Biologie/Chemie (FB 02); Zentrale Wissenschaftliche Einrichtungen und Kooperationen; Institut für Physikalische und Theoretische Chemie; MAPEX Center for Materials and Processes |
| Publication Year: |
2025 |
| Collection: |
State and University Library Bremen: Electronic Library (E-LIB) |
| Subject Terms: |
Absolute configuration; Carbon; Chemical structure; Circular dichroism spectroscopy; Sesquiterpenoids |
| Time: |
540 |
| Description: |
Seven sesquiterpenoids, named nebucanes A–G (1–7), featuring a rare alliacane scaffold with unprecedented furan or pyrrole functions, were isolated from the fermentation broth of Clitocybe nebularis. Their structures were established on the basis of 1D/2D NMR spectroscopic analyses, HR-(+)-ESIMS spectra, and comparison of measured and calculated CD spectra for determination of the absolute configuration. Assessing the biological activities, nebucane D (4) exhibited antifungal effects against Rhodotorula glutinis, while nebucane G (7) displayed significant cytotoxicity against MCF-7 and A431 cell lines. ; 85 ; 10 ; 2363 ; 2371 |
| Document Type: |
report |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Journal of Natural Products; https://doi.org/10.26092/elib/3678 |
| DOI: |
10.26092/elib/3678 |
| Availability: |
https://media.suub.uni-bremen.de/handle/elib/8769; https://doi.org/10.26092/elib/3678; https://nbn-resolving.org/urn:nbn:de:gbv:46-elib87695 |
| Rights: |
Alle Rechte vorbehalten |
| Accession Number: |
edsbas.39C949D8 |
| Database: |
BASE |