| Title: |
Neutrophil Activation and Immune Thrombosis Profiles Persist in Convalescent COVID-19. |
| Authors: |
Hocini, Hakim; Wiedemann, Aurélie; Blengio, Fabiola; Lefebvre, Cécile; Cervantes-Gonzalez, Minerva; Foucat, Emile; Tisserand, Pascaline; Surenaud, Mathieu; Coléon, Séverin; Prague, Mélanie; Guillaumat, Lydia; Krief, Corinne; Fenwick, Craig; Laouénan, Cédric; Bouadma, Lila; Ghosn, Jade; Pantaleo, Giuseppe; Thiébaut, Rodolphe; Lévy, Yves; Abel, L.; Abrous, A.; Andrejak, C.; Angoulvant, F.; Bachelet, D.; Bartoli, M.; Behilill, S.; Beluze, M.; Bhavsar, K.; Chair, A.; Charpentier, C.; Chenard, L.; Chirouze, C.; Couffin-Cadiergues, S.; Couffignal, C.; Castro, N.; Debray, M. P.; Deplanque, Dominique; Descamps, D.; Diallo, A.; Silva, F. D. D.; Dorival, C.; Duval, X.; Eloy, P.; Enouf, V.; Esperou, H.; Esposito-Farese, M.; Etienne, M.; Florence, A. M.; Gaymard, A.; Gigante, T.; Gilg, M.; Goehringer, F.; Guedj, J.; Houas, I.; Hoffmann, I.; Hulot, J. S.; Jaafoura, S.; Jamard, S.; Kafif, O.; Khalil, A.; Lafhej, N.; Laribi, S.; Le, M.; Hingrat, Q. L.; Mestre, S. L.; Letrou, S.; Lina, B.; Lingas, G.; Malvy, D.; Mentré, F.; Mouquet, H.; Neant, N.; Paul, C.; Papadopoulos, A.; Petrov-Sanchez, V.; Peytavin, G.; Piquard, V.; Picone, O.; Rosa-Calatrava, M.; Rossignol, B.; Rossignol, P.; Roy, C.; Schneider, M.; Tardivon, C.; Timsit, J. F.; Tubiana, S.; Werf, S. V.; Visseaux, B. |
| Contributors: |
Université de Lille; Inserm; CHU Lille; IMRB - "NeuroPsychologie Interventionnelle" Créteil U955 Inserm - UPEC; IMRB - "From pathophysiology towards immune-basedinterventions in HIV infection" Créteil U955 Inserm - UPEC; Centre d'investigation Clinique CHU Bichat - Épidémiologie clinique CIC 1425; Infection, Anti-microbiens, Modélisation, Evolution IAME (UMR_S_1137 / U1137); Statistics In System biology and Translational Medicine SISTM; Lille Neurosciences & Cognition (LilNCog) - U 1172 |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
COVID-19 disease; post-acute COVID-19 syndrome; thrombosis |
| Description: |
Purpose Following a severe COVID-19 infection, a proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies the persistence of symptoms months after the resolution of acute COVID-19. Methods We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, and whole blood gene expression profiles in convalescent severe COVID-19 patients 1, 3, and 6 months following hospital discharge. Results We observed persistent abnormalities until month 6 marked by (i) high serum levels of monocyte/macrophage and endothelial activation markers, chemotaxis, and hematopoietic cytokines; (ii) a high frequency of central memory CD4+ and effector CD8+ T cells; (iii) a decrease in anti-SARS-CoV-2 spike and neutralizing antibodies; and (iv) an upregulation of genes related to platelet, neutrophil activation, erythrocytes, myeloid cell differentiation, and RUNX1 signaling. We identified a “core gene signature” associated with a history of thrombotic events, with upregulation of a set of genes involved in neutrophil activation, platelet, hematopoiesis, and blood coagulation. Conclusion The lack of restoration of gene expression to a normal profile after up to 6 months of follow-up, even in asymptomatic patients who experienced severe COVID-19, signals the need to carefully extend their clinical follow-up and propose preventive measures. ; 43 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/rdf+xml; charset=utf-8; application/pdf |
| Language: |
English |
| Relation: |
Journal of Clinical Immunology; http://hdl.handle.net/20.500.12210/101830 |
| Availability: |
https://hdl.handle.net/20.500.12210/101830 |
| Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.39D64F79 |
| Database: |
BASE |