| Title: |
Initial characteristics and follow-up of patients with a confirmed diagnosis of angiotensin-converting enzyme inhibitors-induced angioedema |
| Authors: |
Chépy, Aurélien; Véron, Marie; Gautier, Sophie; Farhat, Meryem-Maud; Pokeerbux, Ryadh; Venturelli, Giorgia; Yelnik, Cécile; Dubucquoi, Sylvain; Podevin, Céline; Jendoubi, Manel; Citerne, Isabelle; Baraffe, Jennifer; Staumont-Sallé, Delphine; Launay, David; Sanges, Sébastien |
| Publisher Information: |
Authorea, Inc. |
| Publication Year: |
2024 |
| Collection: |
The Winnower (via CrossRef) |
| Description: |
Introduction: Differential diagnosis between angiotensin converting enzyme inhibitors (ACEi) angioedema (AE) and idiopathic histaminergic AE (ihAE) is often challenging. Follow-up data may help discriminate these conditions but are scarcely reported. Our objective was to report on the follow-up of patients with suspected ACEi-AE and to describe the baseline characteristics of AE attacks in patients with a diagnosis confirmed by follow-up. Methods: Sixty-four patients with suspected ACEi-AE (i.e. with exposure to ACEi before first attack, no urticaria associated and normal C1-inhibitor levels) and at least one follow-up visit were included. Data were retrospectively collected at baseline and during follow-up. Results: After follow-up, the diagnosis of ACEi-AE was confirmed in only 30 patients. The remaining patients were reclassified as ihAE (21 patients) or undetermined-mechanism AE (13 patients). In ACEi-AE patients, attacks occurred mostly in men (61%) with a median age of 64 (interquartile range 17) years old, with a highly variable delay from ACEi introduction (23103 months), and preferential involvement of lips (50%), tongue (47%) and throat (30%). Patients with confirmed ACEi-AE frequently reported classical histaminergic features, such as history of allergy and atopic conditions (20%), attacks with preferential evening onset (25%) and spontaneous resolution |
| Document Type: |
other/unknown material |
| Language: |
unknown |
| DOI: |
10.22541/au.170665122.24192765/v1 |
| Availability: |
https://doi.org/10.22541/au.170665122.24192765/v1 |
| Accession Number: |
edsbas.39DCE8EE |
| Database: |
BASE |