| Title: |
Characterisation of Mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions |
| Authors: |
Delfino, Giada; Briand, Jean Baptiste; Oullier, Thibauld; Nienkemper, Léa; Greig, Jenny; Véziers, Joëlle; Neunlist, Michel; Derkinderen, Pascal; Paillusson, Sebastien |
| Contributors: |
The Enteric Nervous System in gut and brain disorders U1235 (TENS); Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé; Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ); Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI); Team 2 : Cell and gene engineering in tolerance, fertility and regenerative medicine (Team 2 - U1064 Inserm - CR2TI); Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE); Regenerative Medicine and Skeleton (RMeS); École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie (Nantes Univ – UFR Odonto); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); PO CCI 2014 FR16M20P008/Conseil Régional des Pays de la Loire (Région Pays de la Loire)Fédération pour la Recherche sur le Cerveau (FRC)Amadys; ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016) |
| Source: |
ISSN: 0193-1857. |
| Publisher Information: |
CCSD; American Physiological Society |
| Publication Year: |
2024 |
| Collection: |
Université de Nantes: HAL-UNIV-NANTES |
| Subject Terms: |
Alzheimer's disease; Mitochondria associated ER membranes; Parkinson's disease; ageing; enteric nervous system; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Alterations in endoplasmic reticulum-mitochondria associations and in mitochondria-associated ER membrane (MAM) behaviour have been reported in the brain in several neurodegenerative diseases. Despite the emerging role of the gut-brain axis in neurodegenerative disorders, the biology of MAM in the enteric nervous system (ENS) has not previously been studied. Therefore, we set out to characterise the MAM in the distal colon of wild type C57BL/6J mice and in senescence accelerated mouse prone 8 (SAMP8), a mouse model of age-related neurodegeneration. We showed for the first time that MAM are widely present in enteric neurons and that their association is altered in SAMP8 mice. We then examined the functions of MAM in a primary culture model of enteric neurons and showed that calcium homeostasis was altered in SAMP8 mice when compared to control animals. These findings provide the first detailed characterisation of MAM in the ENS under physiological conditions and during age-associated neurodegeneration. Further investigation of MAM modifications in the ENS in disease may provide valuable information about the possible role of enteric MAM in neurodegenerative diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38226933; PUBMED: 38226933 |
| DOI: |
10.1152/ajpgi.00224.2023 |
| Availability: |
https://inserm.hal.science/inserm-04446267; https://inserm.hal.science/inserm-04446267v1/document; https://inserm.hal.science/inserm-04446267v1/file/delfino-et-al-2024.pdf; https://doi.org/10.1152/ajpgi.00224.2023 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.39E67DE9 |
| Database: |
BASE |