| Title: |
Minocycline in Severe Cerebral Amyloid Angiopathy:A Single-Center Cohort Study |
| Authors: |
Bax,Francesco; Warren,Andrew; Fouks,Avia Abramovitz; van den Brink, Hilde; van Veluw, Susanne J; Kozberg,Mariel G; Greenberg,Steven M; Projectafdeling VCI |
| Publication Year: |
2024 |
| Subject Terms: |
cerebral amyloid angiopathy; intracerebral hemorrhage; matrix metalloproteinases; minocycline; preliminary study; Cardiology and Cardiovascular Medicine |
| Description: |
BACKGROUND: Evidence from animal studies suggests that minocycline may reduce lobar intracerebral hemorrhage (ICH) recurrence in cerebral amyloid angiopathy, possibly by inhibiting perivascular extracellular matrix degradation in cerebral small vessels. There is currently no evidence of its safety or efficacy in humans with cerebral amyloid angiopathy. METHODS AND RESULTS: To provide preliminary data to support future studies of minocycline’s efficacy, the authors performed a retrospective single-center cohort study to assess the incidence of recurrent ICH in patients with an aggressive clinical course of probable cerebral amyloid angiopathy who had been prescribed minocycline off-label via shared decision-making. Crude incidence rate ratios were calculated to compare incidence rates before versus after treatment. Sixteen patients (mean age at minocycline initiation, 66.3±3.5 years; women 62.5%; median of 3 lobar ICHs [range, 1–6]) were initiated on minocycline and followed for a median of 12.4 months (range, 1.8–61.4 months). Adverse events were reported in 4 of 16 patients (gastroenteric, n=3; dizziness, n=1) and were considered mild. ICH incidence sharply increased the year before minocycline initiation compared with the preceding years (2.18 [95% CI, 1.50–3.07] versus 0.40 [95% CI, 0.25–0.60] events per patient-year) and fell to 0.46 (95% CI, 0.23–0.83) events per patient-year afterwards. Incidence rate ratios of recurrent ICH after minocycline was lower (0.21 [95% CI, 0.11–0.42], P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
2047-9980 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/453522 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/453522 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.39EF8DB9 |
| Database: |
BASE |