| Title: |
DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells. |
| Authors: |
Hristova, DB; Oliveira, M; Wagner, E; Melcher, A; Harrington, KJ; Belot, A; Ferguson, BJ |
| Contributors: |
Melcher, Alan; Harrington, Kevin |
| Publisher Information: |
CELL PRESS |
| Publication Year: |
2024 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Subject Terms: |
Molecular biology; Virology |
| Subject Geographic: |
United States |
| Description: |
To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and DNA viruses are sensed are relevant not only to anti-viral innate immunity, but also to autoinflammation and anti-tumour immunity through the initiation of sterile inflammation by self-DNA recognition. The PRRs that directly sense and respond to viral or damaged self-DNA function by signaling to activate interferon regulatory factor (IRF)-dependent type one interferon (IFN-I) transcription. We and others have previously defined DNA-dependent protein kinase (DNA-PK) as an essential component of the DNA-dependent anti-viral innate immune system. Here, we show that DNA-PK is essential for cyclic GMP-AMP synthase (cGAS)- and stimulator of interferon genes (STING)-dependent IFN-I responses in human cells during stimulation with exogenous DNA and infection with DNA viruses. |
| Document Type: |
article in journal/newspaper |
| File Description: |
Electronic-eCollection; application/pdf |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
108760; S2589-0042(23)02837-7; iScience, 2024, 27 (1), pp. 108760 -; https://repository.icr.ac.uk/handle/internal/6187 |
| DOI: |
10.1016/j.isci.2023.108760 |
| Availability: |
https://doi.org/10.1016/j.isci.2023.108760; https://repository.icr.ac.uk/handle/internal/6187 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.3A0C0DC2 |
| Database: |
BASE |