| Title: |
White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
| Authors: |
Byun, JI; Oh, S; Sunwoo, JS; Shin, JW; Kim, TJ; Jun, JS; Kim, HJ; Shin, WC; Seong, JK; Jung, KY |
| Contributors: |
112418; Kim, TJ |
| Publication Year: |
2022 |
| Subject Terms: |
Aged; Anisotropy; Cross-Sectional Studies; Gray Matter; Humans; REM Sleep Behavior Disorder; White Matter; Neuroimaging; Tract-specific statistical analysis; Tractography |
| Description: |
OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. METHODS: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Correlations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. RESULTS: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently correlated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). CONCLUSION: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
J022131582; http://repository.ajou.ac.kr/handle/201003/25036; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791 |
| DOI: |
10.1016/j.nicl.2022.103186 |
| Availability: |
http://repository.ajou.ac.kr/handle/201003/25036; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791; https://doi.org/10.1016/j.nicl.2022.103186 |
| Accession Number: |
edsbas.3A9C6830 |
| Database: |
BASE |