| Title: |
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern |
| Authors: |
Skelly, DT; Harding, AC; Gilbert-Jaramillo, J; Knight, M; Longet, S; Brown, A; Adele, S; Adland, E; Brown, H; Team, Medawar Laboratory; Tipton, T; Stafford, L; Johnson, S; Amini, A; Group, OPTIC Clinical; Kit Tan, T; Schimanski, L; Huang, K-Y; Rijal, P; Group, PITCH Study; Group, Cmore Phosp-C; Frater, J; Goulder, P; Conlon, C; Jeffery, K; Dold, C; Pollard, A; Sigal, A; Oliveira, TD; Townsend, A; Klenerman, P; Dunachie, S; Barnes, E; Carroll, M; James, WS |
| Publisher Information: |
Nature Research |
| Publication Year: |
2021 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41467-021-25167-5 |
| Availability: |
https://doi.org/10.1038/s41467-021-25167-5; https://ora.ox.ac.uk/objects/uuid:4c7c0b62-9f97-40d5-8ecc-627ca3677983 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.3AAFF0AD |
| Database: |
BASE |