| Title: |
Transethnic genome-wide scan identifies novel Alzheimer's disease loci |
| Authors: |
Jun, GR; Chung, J; Mez, J; Barber, R; Beecham, GW; Bennett, DA; Buxbaum, JD; Byrd, GS; Carrasquillo, MM; Crane, PK; Cruchaga, C; De Jager, P; Ertekin-Taner, N; Evans, D; Fallin, MD; Foroud, TM; Friedland, RP; Goate, AM; Graff-Radford, NR; Hendrie, H; Hall, KS; Hamilton-Nelson, KL; Inzelberg, R; Kamboh, MI; Kauwe, JSK; Kukull, WA; Kunkle, BW; Kuwano, R; Larson, EB; Logue, MW; Manly, JJ; Martin, ER; Montine, TJ; Mukherjee, S; Naj, A; Reiman, EM; Reitz, C; Sherva, R; St George-Hyslop, PH; Thornton, T; Younkin, SG; Vardarajan, BN; Wang, L-S; Wendlund, JR; Winslow, AR; Haines, J; Mayeux, R; Pericak-Vance, MA; Schellenberg, G; Lunetta, KL; Farrer, LA |
| Source: |
Alzheimer's & Dementia , 13 (7) pp. 727-738. (2017) |
| Publisher Information: |
ELSEVIER SCIENCE INC |
| Publication Year: |
2017 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Clinical Neurology; Neurosciences & Neurology; Transethnic; Alzheimer's disease; Genome-wide association; APOE interaction; APOLIPOPROTEIN-E GENOTYPE; SUSCEPTIBILITY LOCI; GROWTH-FACTOR; MOUSE MODEL; ASSOCIATION; PROTEIN; METAANALYSIS; BINDING; GENE; APOE |
| Description: |
INTRODUCTION: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. METHODS: We conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. RESULTS: Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)–based tests (P < 5 × 10−8) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence (P < 2.7 × 10−6) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 × 10−6). DISCUSSION: Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10025982/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10025982/1/1-s2.0-S1552526017300031-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10025982/ |
| Rights: |
open |
| Accession Number: |
edsbas.3AC5C452 |
| Database: |
BASE |