| Title: |
Microenvironment drug resistance in multiple myeloma: Emerging new players |
| Authors: |
DI MARZO, LUCIA; DESANTIS, VANESSA; SOLIMANDO, ANTONIO GIOVANNI; RUGGIERI, SIMONA; ANNESE, TIZIANA; NICO, Beatrice; FUMARULO, Ruggiero; VACCA, Angelo; Frassanito, Maria Antonia |
| Contributors: |
DI MARZO, Lucia; Desantis, Vanessa; Solimando, ANTONIO GIOVANNI; Ruggieri, Simona; Annese, Tiziana; Nico, Beatrice; Fumarulo, Ruggiero; Vacca, Angelo; Frassanito, Maria Antonia |
| Publication Year: |
2016 |
| Collection: |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| Subject Terms: |
Cancer-associated fibroblast; Drug resistance; Exosome; MicroRNA; Multiple myeloma; Oncology |
| Description: |
Multiple myeloma (MM) drug resistance (DR) is a multistep transformation process based on a powerful interplay between bone marrow stromal cells and MM cells that allows the latter to escape anti-myeloma therapies. Here we present an overview of the role of the bone marrow microenvironment in both soluble factors mediated drug resistance (SFM-DR) and cell adhesion-mediated drug resistance (CAMDR), focusing on the role of new players, namely miRNAs, exosomes and cancerassociated fibroblasts. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/27474171; info:eu-repo/semantics/altIdentifier/wos/WOS:000387153900145; volume:7; issue:37; firstpage:60698; lastpage:60711; numberofpages:14; journal:ONCOTARGET; https://hdl.handle.net/11586/180493; http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path[]=10849&path[]=34345 |
| DOI: |
10.18632/oncotarget.10849 |
| Availability: |
https://hdl.handle.net/11586/180493; https://doi.org/10.18632/oncotarget.10849; http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path[]=10849&path[]=34345 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.3ACC4F09 |
| Database: |
BASE |