MOLGENIS Armadillo:A lightweight server for federated analysis using DataSHIELD
| Title: | MOLGENIS Armadillo:A lightweight server for federated analysis using DataSHIELD |
|---|---|
| Authors: | Cadman, Tim; Slofstra, Mariska K.; Van Der Geest, Marije A.; Avraam, Demetris; Bishop, Tom R.P.; De Boer, Tommy; Duijts, Liesbeth; Haakma, Sido; Hyde, Eleanor; Jaddoe, Vincent; Karramass, Tarik; Kelpin, Fleur; Marcon, Yannick; Pinot De Moira, Angela; Postma, Dick; Tolboom, Clemens; Veenstra, Ruben L.; Wheater, Stuart; Welten, Marieke; Wilson, Rebecca C.; Zwart, Erik; Swertz, Morris |
| Source: | Cadman, T, Slofstra, M K, Van Der Geest, M A, Avraam, D, Bishop, T R P, De Boer, T, Duijts, L, Haakma, S, Hyde, E, Jaddoe, V, Karramass, T, Kelpin, F, Marcon, Y, Pinot De Moira, A, Postma, D, Tolboom, C, Veenstra, R L, Wheater, S, Welten, M, Wilson, R C, Zwart, E & Swertz, M 2025, 'MOLGENIS Armadillo : A lightweight server for federated analysis using DataSHIELD', Bioinformatics, vol. 41, no. 1, btae726. https://doi.org/10.1093/bioinformatics/btae726 |
| Publication Year: | 2025 |
| Subject Terms: | /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being; name=SDG 3 - Good Health and Well-being |
| Description: | Extensive human health data from cohort studies, national registries, and biobanks can reveal lifecourse risk factors impacting health. Combining these sources offers increased statistical power, rare outcome detection, replication of findings, and extended study periods. Traditionally, this required data transfer to a central location or separate partner analyses with pooled summary statistics, posing ethical, legal, and time constraints. Federated analysis-which involves remote data analysis without sharing individual-level data-is a promising alternative. One promising solution is DataSHIELD (https://datashield.org/), an open-source R based implementation. To enable federated analysis, data owners need a user-friendly way to install the federated infrastructure and manage users and data. Here, we present MOLGENIS Armadillo: A lightweight server for federated analysis solutions such as DataSHIELD. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1367-4803; 1367-4811 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39673440; info:eu-repo/semantics/altIdentifier/pissn/1367-4803; info:eu-repo/semantics/altIdentifier/eissn/1367-4811 |
| DOI: | 10.1093/bioinformatics/btae726 |
| Availability: | https://pure.eur.nl/en/publications/47d631d6-2860-41d3-ad02-4e3db4e001d5; https://doi.org/10.1093/bioinformatics/btae726; https://pure.eur.nl/ws/files/181820480/MOLGENIS_Armadillo.pdf; https://www.scopus.com/pages/publications/85215378364 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.3AEBA270 |
| Database: | BASE |