| Title: |
Duration of dual antiplatelet therapy after percutaneous coronary intervention of unprotected left main coronary artery stenosis: 6 versus 12 months |
| Authors: |
Hartikainen, Tau; Mertins, Sina; Behrens, Max; Neumann, Franz-Josef; Valina, Christian Marc; Löffelhardt, Nikolaus; Rahimi Nedjat, Faridun Daniel; Breitbart, Philipp; Franke, Kilian; Westermann, D.; Ferenc, Miroslaw |
| Source: |
Journal of Clinical Medicine. - 13, 18 (2024) , 5449, ISSN: 2077-0383 |
| Publication Year: |
2024 |
| Collection: |
University of Freiburg: FreiDok |
| Description: |
Background/Objectives: For patients with percutaneous coronary intervention (PCI) of an unprotected left main coronary artery (uLMCA) stenosis, the optimal duration of dual antiplatelet therapy (DAPT) remains a matter of debate. The purpose of this study was to compare clinical outcomes of 6- versus 12-month DAPT duration in patients with PCI of an uLMCA and stable angina. Methods: In this retrospective analysis, we included consecutive patients of our centre who underwent PCI of uLMCA stenosis for stable angina and who received DAPT with acetylsalicylic acid and clopidogrel for either 6 or 12 months. The primary endpoint was the composite of all-cause mortality, myocardial infarction, and target lesion revascularization at one year. Secondary endpoints included individual components of the primary endpoint, definite/probable stent thrombosis, and bleeding. Clinical outcomes were assessed by unadjusted analysis and by inverse probability of treatment weighting (IPTW). Results: Out of 984 included patients, 339 (34.5%) received DAPT for 6 months and 645 (65.5%) for 12 months. The primary endpoint occurred in 51 patients (15.2%) in the 6-month group and in 104 (16.3%) in the 12-month group (p = 0.674). Incidences of stent thrombosis (0.9% versus 0.3%, p = 0.224) and BARC 3,4,5 bleeding (6% versus 5.8%, p = 0.808) were also comparable in both groups. We found no significant differences in the primary endpoint and its components or BARC 3,4,5 bleeding between 6 and 12 months. Conclusions: Our findings do not support the extension of DAPT beyond 6 months after PCI for uLMCA in patients with stable angina. |
| Document Type: |
article in journal/newspaper |
| File Description: |
pdf |
| Language: |
English |
| Relation: |
https://freidok.uni-freiburg.de/data/256979 |
| DOI: |
10.3390/jcm13185449 |
| Availability: |
https://freidok.uni-freiburg.de/data/256979; https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2569792; https://doi.org/10.3390/jcm13185449; https://freidok.uni-freiburg.de/dnb/download/256979 |
| Rights: |
free |
| Accession Number: |
edsbas.3B1893A7 |
| Database: |
BASE |