| Title: |
Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception |
| Authors: |
Caballero-Posadas, Ignacio; Mbouamboua, Yvon; Weise, Susanne; López-Gálvez, Raquel; Couralet, Marie; Fleurot, Isabelle; Pons, Nicolas; Barrera-Conde, Marta; Quílez-Playán, Nayima; Keller, Matthieu; Klymiuk, Nikolai; Robledo, Patricia; Hummel, Thomas; Barbry, Pascal; Chamero, Pablo |
| Contributors: |
Infectiologie et Santé Publique (ISP); Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Institut de pharmacologie moléculaire et cellulaire (IPMC); Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA); University Hospital Carl Gustav Carus Dresden, Germany; Technische Universität Dresden = Dresden University of Technology (TU Dresden); Physiologie de la reproduction et des comportements Nouzilly (PRC); Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); IMIM-Hospital del Mar; Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia = Généralité de Catalogne; Universitat Pompeu Fabra Barcelona (UPF); Klinikum rechts der Isar (MRI TUM); Technische Universität Munchen = Technical University Munich = Université Technique de Munich (TUM); Ludwig Maximilian University Munich = Ludwig Maximilians Universität München (LMU); Centre National de la Recherche Scientifique (CNRS); Université Côte d'Azur (UniCA); Vaincre la Mucoviscidose Association grant nos. RF20200502689 (to i.C. and P.C.) and RF20180502280 (to P.B. and i.C.), the Region Centre val de loire grant no. 201900134883 (to P.C.), the Conseil départemental des Alpes Maritimes grant no. 2016- 294dGAdSh- CV to PB); ANR-20-CE92-0003,LOFTER,Connexions entre les systèmes olfactif et limbique : des odeurs au comportement(2020); ANR-18-CE20-0024,PIGIMMUNITY,PIGIMMUNITY: une approche de biologie des systèmes pour stimuler la réponse innée chez le porc(2018); ANR-10-INBS-0009,France Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010); ANR-23-IAHU-0007,RespirERA,Santé Respiratoire, Environnement et Vieillissement(2023); ANR-19-P3IA-0002,3IA@cote d'azur,3IA Côte d'Azur(2019) |
| Source: |
ISSN: 2375-2548 ; Science Advances ; https://hal.inrae.fr/hal-05006969 ; Science Advances , 2025, 11 (9), pp.eads1568. ⟨10.1126/sciadv.ads1568⟩ ; https://www.science.org/doi/10.1126/sciadv.ads1568. |
| Publisher Information: |
CCSD; American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2025 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; A reduced sense of smell is a common condition in people with cystic fibrosis (CF) that negatively affects their quality of life. While often attributed to nasal mucosa inflammation, the underlying causes of the olfactory loss remain unknown. Here, we characterized gene expression in olfactory epithelium cells from patients with CF using single-nuclei RNA sequencing and found altered expression of olfactory receptors (ORs) and genes related to progenitor cell proliferation. We confirmed these findings in newborn, inflammation-free samples of a CF animal model and further identified ultrastructural alterations in the olfactory epithelium and bulbs of these animals. We established that CFTR, the anion channel whose dysfunction causes CF, is dispensable for odor-evoked signaling in sensory neurons, yet CF animals displayed defective odor-guided behaviors consistent with the morphological and molecular alterations. Our study highlights CF’s major role in modulating epithelial structure and OR expression, shedding light on the mechanisms contributing to olfactory loss in CF. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-0-01-434710-0; 0-01-434710-5 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40020072; PUBMED: 40020072; PUBMEDCENTRAL: PMC11870070; WOS: 001434710500009 |
| DOI: |
10.1126/sciadv.ads1568 |
| Availability: |
https://hal.inrae.fr/hal-05006969; https://hal.inrae.fr/hal-05006969v1/document; https://hal.inrae.fr/hal-05006969v1/file/2025_Caballero_Sci-Adv_vol-11_art-eads1568.pdf; https://doi.org/10.1126/sciadv.ads1568 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.3B7DDA98 |
| Database: |
BASE |