| Title: |
The Impact of Formulation on Lutein, Zeaxanthin, and meso-Zeaxanthin Bioavailability: A Randomised Double-Blind Placebo-Controlled Study |
| Authors: |
Green-Gomez, Marina; Prado-Cabrero, Alfonso; Moran, Rachel; Power, Tommy; Gómez Gómez-Mascaraque, Laura; Stack, Jim; Nolan, John N. |
| Contributors: |
Howard Foundation UK; Waterford Institute of Technology (WIT) President’s scholarship program |
| Source: |
9 ; 8 ; 767 ; Antioxidants |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2020 |
| Collection: |
Teagasc (The Irish Agriculture and Food Development Authority): T-Stór |
| Subject Terms: |
meso-zeaxanthin; Zeaxanthin; Lutein; carotenoid diacetates; bioavailability; micromicelles |
| Description: |
peer-reviewed ; Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Antioxidants;vol 9; http://hdl.handle.net/11019/2353; https://doi.org/10.3390/antiox9080767; antiox9080767 |
| DOI: |
10.3390/antiox9080767 |
| Availability: |
http://hdl.handle.net/11019/2353; https://doi.org/10.3390/antiox9080767 |
| Rights: |
Attribution-NonCommercial-ShareAlike 4.0 International ; http://creativecommons.org/licenses/by-nc-sa/4.0/ |
| Accession Number: |
edsbas.3BB55797 |
| Database: |
BASE |