| Title: |
Cardiac interoception in Anorexia Nervosa: A resting-state heartbeat-evoked potential study |
| Authors: |
Cambi S; Solcà M; Micali N; Berchio C. |
| Contributors: |
Cambi, S; Solcà, M; Micali, N; Berchio, C. |
| Publication Year: |
2024 |
| Collection: |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| Subject Terms: |
EEG; anorexia nervosa; cardiac; heartbeat‐evoked potential; interoception |
| Description: |
Objective: A deficit in interoception - the ability to perceive, interpret and integrate afferent signals about the physiological state of the body - has been shown in Anorexia Nervosa (AN), and linked to altered hunger sensations, body dysmorphia, and abnormal emotional awareness. The present high-density electroencephalography (hdEEG) study aims to assess cardiac interoception in AN and to investigate its neural correlates, using an objective neurophysiological measure. Method: Heartbeat-evoked potentials (HEPs) were computed from 5 min of resting-state EEG and electrocardiogram (ECG) data and compared between individuals with AN (N = 22) and healthy controls (HC) (N = 19) with waveform, topographic, and source imaging analyses. Results: Differences in the cortical representation of heartbeats were present between AN and HC at a time window of 332-348 ms after the ECG R-peak. Source imaging analyses revealed a right-sided hypoactivation in AN of brain regions linked to interoceptive processing, such as the anterior cingulate and orbitofrontal areas. Conclusions: To the best of our knowledge, this is the first study using hdEEG to localise the underlying sources of HEPs in AN. Results point to altered interoceptive processing during resting-state in AN. As our participants had a short duration of illness, this might not be the consequence of prolonged starvation. Interventions targeted at interoception could provide an additional tool to facilitate recovery. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38009624; volume:32; issue:3; firstpage:417; lastpage:430; numberofpages:14; journal:EUROPEAN EATING DISORDERS REVIEW; https://hdl.handle.net/11586/505673 |
| DOI: |
10.1002/erv.3049 |
| Availability: |
https://hdl.handle.net/11586/505673; https://doi.org/10.1002/erv.3049 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.3BF44F0C |
| Database: |
BASE |