| Title: |
Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells |
| Authors: |
Georgiadou, E; Rutter, GA |
| Contributors: |
MRC Programme Grant; Medical Research Council (MRC); Wellcome Trust; INNOVATIVE MEDICINES INITIATIVE; Diabetes UK; Biotechnology and Biological Sciences Research Council (BBSRC); The Royal Society; European Foundation for the Study of Diabetes; Sun Pharmaceutical Industries Limited |
| Publisher Information: |
Elsevier |
| Publication Year: |
2020 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
Ca(2+); Insulin secretion; Mitochondria; Type 2 diabetes; β-cells; Biochemistry & Molecular Biology; 0601 Biochemistry and Cell Biology; 0606 Physiology; 1116 Medical Physiology |
| Subject Geographic: |
Netherlands |
| Description: |
Mitochondria play a central role in glucose metabolism and the stimulation of insulin secretion from pancreatic β-cells. In this review, we discuss firstly the regulation and roles of mitochondrial Ca2+ transport in glucose-regulated insulin secretion, and the molecular machinery involved. Next, we discuss the evidence that mitochondrial dysfunction in β-cells is associated with type 2 diabetes, from a genetic, functional and structural point of view, and then the possibility that these changes may in part be mediated by dysregulation of cytosolic Ca2+. Finally, we review the importance of preserved mitochondrial structure and dynamics for mitochondrial gene expression and their possible relevance to the pathogenesis of type 2 diabetes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Cell Calcium; http://hdl.handle.net/10044/1/84203; MR/R022259/1; MR/R010676/1; 212625/Z/18/Z; 097816/Z/11/ZR; 105603/Z/14/Z; 098424/Z/12/ZR; MR/K001981/1; MR/N020472/1; MR/L02036X/1; 115881; 15 / 0005275; MR/M012646/1; R26199/CN001; 15821; BB/J015873/1; 12/0004601; WM100078; MR/K023667/1; N/A; 15/0005374; BDA number 13/0004672; 13/0004672 |
| DOI: |
10.1016/j.ceca.2020.102282 |
| Availability: |
http://hdl.handle.net/10044/1/84203; https://doi.org/10.1016/j.ceca.2020.102282 |
| Rights: |
© 2020 Published by Elsevier Ltd. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence http://creativecommons.org/licenses/by-nc-nd/4.0/ ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.3C0F1F34 |
| Database: |
BASE |