| Title: |
Significance of Neutrophil-to-lymphocyte Ratio in Western Advanced EGFR-mutated Non-small Cell Lung Cancer Receiving a Targeted Therapy |
| Authors: |
Meriggi, Fausto; Codignola, Claudio; Beretta, Giordano D.; Ceresoli, Giovanni L.; Caprioli, Alberto; Scartozzi, Mario; Fraccon, Anna P.; Prochilo, Tiziana; Ogliosi, Chiara; Zaniboni, Alberto |
| Source: |
Tumori Journal ; volume 103, issue 5, page 443-448 ; ISSN 0300-8916 2038-2529 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2017 |
| Description: |
Purpose Lung cancer is one of the leading causes of cancer-related death worldwide and, although targeted therapy with tyrosine kinase inhibitors has dramatically improved the rates of response and survival in advanced EGFR-mutated adenocarcinoma, the overall outcome remains unsatisfactory. Therefore, new prognostic factors, preferably simple, inexpensive, and easy to reproduce on a large scale, are needed. We performed a retrospective analysis of our database including 63 western Caucasian patients with advanced EGFR-mutated lung adenocarcinoma and receiving gefitinib, erlotinib, or afatinib as first- or second-line therapy. Several studies demonstrated a strong link between elevated neutrophil-to-lymphocyte ratio (NLR) and poor prognosis both in early and advanced stages of non-small-cell lung cancer (NSCLC). Methods From January 2011 to December 2015, 63 consecutive elegible patients with advanced EGFR-mutated NSCLC were included in this analysis from 5 institutions. The NLR was derived from the absolute neutrophil and the absolute lymphocyte counts of a full blood count and the cutoff value was determined according to the mean NLR level. Results Despite the small sample analyzed, we found that NLR has a prognostic role for progression-free survival (PFS) and overall survival (OS), reaching a statistically significant difference with a better PFS and OS in the lower NLR group. Conclusions Pretreatment NLR seems to represent a reliable, simple, and easy to reproduce laboratory tool to predict outcome and response to cancer therapies in this setting of Western Caucasian patients with EGFR-mutated NSCLC. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.5301/tj.5000632 |
| Availability: |
https://doi.org/10.5301/tj.5000632; https://journals.sagepub.com/doi/pdf/10.5301/tj.5000632; https://journals.sagepub.com/doi/full-xml/10.5301/tj.5000632 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.3C592ACA |
| Database: |
BASE |