| Title: |
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods |
| Authors: |
Mesinovic, Munib; Wong, Xin Ci; Rajahram, Giri Shan; Citarella, Barbara Wanjiru; Peariasamy, Kalaiarasu; van Someren Greve, Frank; Olliaro, Piero; Merson, Laura; Clifton, Lei; Kartsonaki, Christiana; Abdukahil, Sheryl Ann; Abdulkadir, Nurul Najmee; Abe, Ryuzo; Abel, Laurent; Abrous, Amal; Absil, Lara; Acker, Andrew; Adachi, Shingo; Adam, Elisabeth; Adriano, Enrico; Adrião, Diana; Ageel, Saleh Al; Ahmed, Shakeel; Aiello, Marina; Ainscough, Kate; Airlangga, Eka; Aisa, Tharwat; Hssain, Ali Ait; Tamlihat, Younes Ait; Akimoto, Takako; Akmal, Ernita; Qasim, Eman Al; Alalqam, Razi; Alberti, Angela; Al-Dabbous, Tala; Alegesan, Senthilkumar; Alegre, Cynthia; Alessi, Marta; Alex, Beatrice; Alexandre, Kévin; Al-Fares, Abdulrahman; Alfoudri, Huda; Ali, Adam; Ali, Imran; Alidjnou, Kazali Enagnon; Aliudin, Jeffrey; Alkhafajee, Qabas; Allavena, Clotilde; Allou, Nathalie; Alves, João; Alves, João Melo; Alves, Rita; Cabrita, Joana Alves; Amaral, Maria; Amira, Nur; Ammerlaan, Heidi; Ampaw, Phoebe; Andini, Roberto; Andréjak, Claire; Angheben, Andrea; Angoulvant, François; Ansart, Séverine; Anthonidass, Sivanesen; Antonelli, Massimo; de Brito, Carlos Alexandre Antunes; Anwar, Kazi Rubayet; Apriyana, Ardiyan; Arabi, Yaseen; Aragao, Irene; Arancibia, Francisco; Araujo, Carolline; Arcadipane, Antonio; Archambault, Patrick; Arenz, Lukas; Arlet, Jean-Benoît; Arnold-Day, Christel; Arora, Lovkesh; Arora, Rakesh; Artaud-Macari, Elise; Aryal, Diptesh; Asaki, Motohiro; Asensio, Angel; Ashley, Elizabeth; Ashraf, Muhammad; Assie, Jean Baptiste; Asyraf, Amirul; Atique, Anika; Attanyake, Am Udara Lakshan; Auchabie, Johann; Aumaitre, Hugues; Auvet, Adrien; Azemar, Laurène; Azoulay, Cecile; Bach, Benjamin; Bachelet, Delphine; Badr, Claudine; Baig, Nadia; Baillie, J. Kenneth; Baird, J Kevin; Bak, Erica; Bakakos, Agamemnon; Bakar, Nazreen Abu; Bal, Andriy; Balakrishnan, Mohanaprasanth; Balan, Valeria; Bani-Sadr, Firouzé; Barbalho, Renata; Barbosa, Nicholas Yuri; Barclay, Wendy; Barnett, Saef Umar; Barnikel, Michaela; Barrasa, Helena; Barrelet, Audrey; Barrigoto, Cleide; Bartoli, Marie; Baruch, Joaquín; Basmaci, Romain; Basri, Muhammad Fadhli Hassin; Battaglini, Denise; Bauer, Jules; Rincon, Diego Fernando Bautista; Dow, Denisse Bazan; Beane, Abigail; Bedossa, Alexandra; Bee, Ker Hong; Begum, Husna; Behilill, Sylvie; Beishuizen, Albertus; Beljantsev, Aleksandr; Bellemare, David; Beltrame, Anna; Beltrão, Beatriz Amorim; Beluze, Marine; Benech, Nicolas; Benjiman, Lionel Eric; Benkerrou, Dehbia; Bennett, Suzanne; Bento, Luís; Berdal, Jan-Erik; Bergeaud, Delphine; Bergin, Hazel; Bertoli, Giulia; Bertolino, Lorenzo; Bessis, Simon; Betz, Adam; Bevilcaqua, Sybille; Bezulier, Karine; Bhatt, Amar; Bhavsar, Krishna; Bianco, Claudia; Bidin, Farah Nadiah; Singh, Moirangthem Bikram; Humaid, Felwa Bin; Kamarudin, Mohd Nazlin Bin; Bisoffi, Zeno; Bissuel, François; Biston, Patrick; Bitker, Laurent; Bitton, Jonathan; Blanco-Schweizer, Pablo; Blier, Catherine; Bloos, Frank; Blot, Mathieu; Blumberg, Lucille; Boccia, Filomena; Bodenes, Laetitia; Bogaert, Debby; Boivin, Anne-Hélène; Bolaños, Isabela; Bolze, Pierre-Adrien; Bompart, François; Bonelli, Patrizia; Bonfasius, Aurelius; Borges, Diogo; Borie, Raphaël; Bosse, Hans Martin; Botelho-Nevers, Elisabeth; Bouadma, Lila; Bouchaud, Olivier; Bouchez, Sabelline; Bouhmani, Dounia; Bouhour, Damien; Bouiller, Kévin; Bouillet, Laurence; Bouisse, Camile; Bounphiengsy, Thipsavanh; Bountthasavong, Latsaniphone; Boureau, Anne-Sophie; Bourke, John; Bouscambert, Maude; Bousquet, Aurore; Bouziotis, Jason; Boxma, Bianca; Boyer-Besseyre, Marielle; Boylan, Maria; Bozza, Fernando Augusto; Braconnier, Axelle; Braga, Cynthia; Brandenburger, Timo; Monteiro, Filipa Brás; Brazzi, Luca; Breen, Dorothy; Breen, Patrick; Brewster, David; Brickell, Kathy; Browne, Alex; Browne, Shaunagh; Brozzi, Nicolas; Brusse-Keizer, Marjolein; Buchtele, Nina; Bugaeva, Polina; Buisson, Marielle; Buonsenso, Danilo; Burhan, Erlina; Burrell, Aidan; Bustos, Ingrid; Butnaru, Denis; Cabie, André; Cabral, Susana; Caceres, Eder; Cadoz, Cyril; Garcês, Rui Caetano; Callahan, Mia; Calligy, Kate; Calvache, Jose Andres; Caminiti, Caterina; Camões, João; Campana, Valentine; Campbell, Paul; Campisi, Josie; Canepa, Cecilia; Cantero, Mireia; Caraux-Paz, Pauline; Cárcel, Sheila; Cardellino, Chiara Simona; Cardoso, Filipa; Cardoso, Filipe; Cardoso, Nelson; Cardoso, Sofia; Carelli, Simone; Carlacci, Francesca; Carlier, Nicolas; Carmoi, Thierry; Carney, Gayle; Carqueja, Inês; Carret, Marie-Christine; Carrier, François Martin; Carroll, Ida; Carson, Gail; Carvalho, Leonor; Casanova, Maire-Laure; Cascão, Mariana; Casey, Siobhan; Casimiro, José; Cassandra, Bailey; Castañeda, Silvia; Castanheira, Nidyanara; Castor-Alexandre, Guylaine; Castro, Ivo; Catarino, Ana; Catherine, François-Xavier; Cattaneo, Paolo; Cavalin, Roberta; Cavalli, Giulio Giovanni; Cavayas, Alexandros; Ceccato, Adrian; Cerkovnik, Shelby; Cervantes-Gonzalez, Minerva; Chair, Anissa; Chakveatze, Catherine; Chaleunphon, Bounthavy; Chan, Adrienne; Chand, Meera; Auger, Christelle Chantalat; Chapplain, Jean-Marc; Charpentier, Charlotte; Chas, Julie; Chatterjee, Allegra; Iñiguez, Jonathan Samuel Chávez; Chen, Anjellica; Chenard, Léo; Cheng, Matthew Pellan; Cheret, Antoine; Chetta, Alfredo Antonio; Chiarabini, Thibault; Chica, Julian; Chidambaram, Suresh Kumar; Tho, Leong Chin; Chirouze, Catherine; Chiumello, Davide; Cho, Hwa Jin; Cho, Sung-Min; Cholley, Bernard; Chommanam, Danoy; Chopin, Marie-Charlotte; Chow, Ting Soo; Chow, Yock Ping; Christy, Nathaniel; Chua, Hiu Jian; Chua, Jonathan; Cidade, Jose Pedro; Herreros, José Miguel Cisneros; Ciullo, Anna; Clarke, Emma; Clarke, Jennifer; Granado, Rolando Claure-Del; Clohisey, Sara; Codan, Cassidy; Cody, Caitriona; Coelho, Alexandra; Coles, Jennifer; Coles, Megan; Colin, Gwenhaël; Collins, Michael; Colombo, Sebastiano Maria; Combs, Pamela; Connor, Marie; Conrad, Anne; Contreras, Sofía; Conway, Elaine; Cooke, Graham; Copland, Mary; Cordel, Hugues; Corley, Amanda; Cornelis, Sabine; Cornet, Alexander Daniel; Corpuz, Arianne Joy; Cortegiani, Andrea; Corvaisier, Grégory; Costigan, Emma; Couffignal, Camille; Couffin-Cadiergues, Sandrine; Courtois, Roxane; Cousse, Stéphanie; Cregan, Rachel; D’orleans, Charles Crepy; Cristella, Cosimo; Croonen, Sabine; Crowl, Gloria; Crump, Jonathan; Cruz, Claudina; Csete, Marc; Cullen, Ailbhe; Cummings, Matthew; Curley, Ger; Curlier, Elodie; Curran, Colleen; Custodio, Paula; da Silva Filipe, Ana; da Silveira, Charlene; Dabaliz, Al-Awwab; Dagens, Andrew; Dahly, Darren; Dalton, Heidi; Dalton, Jo; Daly, Seamus; Damas, Juliana; Daneman, Nick; Daniel, Corinne; Dankwa, Emmanuelle; Dantas, Jorge; D’aragon, Frédérick; de Jong, Menno; de Loughry, Gillian; de Mendoza, Diego; de Montmollin, Etienne; de Oliveira França, Rafael Freitas; de Pinho Oliveira, Ana Isabel; de Rosa, Rosanna; de Rose, Cristina; de Silva, Thushan; de Vries, Peter; Deacon, Jillian; Dean, David; Debard, Alexa; Debray, Marie-Pierre; Decastro, Nathalie; Dechert, William; Deconninck, Lauren; Decours, Romain; Defous, Eve; Delacroix, Isabelle; Delaveuve, Eric; Delavigne, Karen; Delfos, Nathalie; Deligiannis, Ionna; Dell’amore, Andrea; Delmas, Christelle; Delobel, Pierre; Delsing, Corine; Demonchy, Elisa; Denis, Emmanuelle; Deplanque, Dominique; Depuydt, Pieter; Desai, Mehul; Descamps, Diane; Desvallées, Mathilde; Dewayanti, Santi; Dhanger, Pathik; Diallo, Alpha; Diamantis, Sylvain; Dias, André; Dias, Andrea; da Silva, Fernanda Dias; Diaz, Juan Jose; Diaz, Priscila; Diaz, Rodrigo; Didier, Kévin; Diehl, Jean-Luc; Dieperink, Wim; Dimet, Jérôme; Dinot, Vincent; Diop, Fara; Diouf, Alphonsine; Dishon, Yael; Djossou, Félix; Docherty, Annemarie; Doherty, Helen; Dondorp, Arjen; Dong, Andy; Donnelly, Christl; Donnelly, Maria; Donohue, Chloe; Donohue, Sean; Donohue, Yoann; Doran, Peter; Dorival, Céline; D’ortenzio, Eric; Douangdala, Phouvieng; Douglas, James Joshua; Douma, Renee; Dournon, Nathalie; Downer, Triona; Downey, Joanne; Downing, Mark; Drake, Tom; Driscoll, Aoife; Dryden, Murray; Fonseca, Claudio Duarte; Dubee, Vincent; Dubos, François; Dubot-Pérès, Audrey; Ducancelle, Alexandre; Duculan, Toni; Dudman, Susanne; Duggal, Abhijit; Dunand, Paul; Dunning, Jake; Duplaix, Mathilde; Durante-Mangoni, Emanuele; Durham, Lucian; Dussol, Bertrand; Duthoit, Juliette; Duval, Xavier; Dyrhol-Riise, Anne Margarita; Ean, Sim Choon; Echeverria-Villalobos, Marco; Economopoulos, Giorgio; Egan, Siobhan; Eira, Carla; Sanharawi, Mohamed El; Elapavaluru, Subbarao; Elharrar, Brigitte; Ellerbroek, Jacobien; Eloy, Philippine; Elshazly, Tarek; Elyazar, Iqbal; Enderle, Isabelle; Endo, Tomoyuki; Eng, Chan Chee; Engelmann, Ilka; Enouf, Vincent; Epaulard, Olivier; Escher, Martina; Esperatti, Mariano; Esperou, Hélène; Santo, Catarina Espírito; Esposito-Farese, Marina; Estevão, João; Etienne, Manuel; Ettalhaoui, Nadia; Everding, Anna Greti; Evers, Mirjam; Fabre, Isabelle; Fabre, Marc; Faheem, Amna; Fahy, Arabella; Fairfield, Cameron; Fakar, Zul; Faria, Pedro; Fateena, Hanan; Fatoni, Arie Zainul; Faure, Karine; Favory, Raphaël; Fayed, Mohamed; Feely, Niamh; Feeney, Laura; Fernandes, Jorge; Fernandes, Marília Andreia; Fernandes, Susana; Ferrand, François-Xavier; Devouge, Eglantine Ferrand; Ferrão, Joana; Ferrari, Carlo; Ferraz, Mário; Ferreira, Benigno; Ferreira, Bernardo; Ferreira, Isabel; Ferreira, Sílvia; Ferrer-Roca, Ricard; Ferriere, Nicolas; Ficko, Céline; Figueiredo-Mello, Claudia; Finlayson, William; Fiorda, Juan; Flament, Thomas; Flateau, Clara; Fletcher, Tom; Florence, Aline-Marie; Florio, Letizia Lucia; Flynn, Brigid; Flynn, Deirdre; Fogliazza, Federica; Foley, Claire; Foley, Jean; Fomin, Victor; Fonseca, Tatiana; Fontela, Patricia; Forsyth, Simon; Foster, Denise; Foti, Giuseppe; Fourn, Erwan; Fowler, Robert; Fraher, Marianne; Franch-Llasat, Diego; Fraser, Christophe; Fraser, John; Freire, Marcela Vieira; Ribeiro, Ana Freitas; Friedrich, Caren; Fritz, Ricardo; Fry, Stéphanie; Fuentes, Nora; Fukuda, Masahiro; G, Argin; Gaborieau, Valérie; Gaci, Rostane; Gagliardi, Massimo; Gagnard, Jean-Charles; Gagneux-Brunon, Amandine; Gaião, Sérgio; Skeie, Linda Gail; Gallagher, Phil; Curto, Elena Gallego; Gamble, Carrol; Gani, Yasmin; Garan, Arthur; Garcia, Rebekha; Garcia-Diaz, Julia; Garcia-Gallo, Esteban; Garimella, Navya; Garofalo, Federica; Garot, Denis; Garrait, Valérie; Gault, Nathalie; Gavin, Aisling; Gavrylov, Anatoliy; Gaymard, Alexandre; Gebauer, Johannes; Geraud, Eva; Morlaes, Louis Gerbaud; Germano, Nuno; Ghisulal, Praveen Kumar; Ghosn, Jade; Giani, Marco; Giaquinto, Carlo; Gibson, Jess; Gigante, Tristan; Gilg, Morgane; Gilroy, Elaine; Giordano, Guillermo; Girvan, Michelle; Gissot, Valérie; Glikman, Daniel; Glybochko, Petr; Gnall, Eric; Goco, Geraldine; Goehringer, François; Goepel, Siri; Goffard, Jean-Christophe; Goh, Jin Yi; Golob, Jonathan; Gomes, Rui; Gomez, Kyle; Gómez-Junyent, Joan; Gominet, Marie; Gonzalez, Alicia; Gordon, Patricia; Gorenne, Isabelle; Goubert, Laure; Goujard, Cécile; Goulenok, Tiphaine; Grable, Margarite; Graf, Jeronimo; Grandin, Edward Wilson; Granier, Pascal; Grasselli, Giacomo; Green, Christopher; Greene, Courtney; Greenhalf, William; Greffe, Segolène; Grieco, Domenico Luca; Griffee, Matthew; Griffiths, Fiona; Grigoras, Ioana; Groenendijk, Albert; Lordemann, Anja Grosse; Gruner, Heidi; Gu, Yusing; Guedj, Jérémie; Guego, Martin; Guellec, Dewi; Guerguerian, Anne-Marie; Guerreiro, Daniela; Guery, Romain; Guillaumot, Anne; Guilleminault, Laurent; de Castro, Maisa Guimarães; Guimard, Thomas; Haalboom, Marieke; Haber, Daniel; Habraken, Hannah; Hachemi, Ali; Hadri, Nadir; Hakak, Sheeba; Hall, Adam; Hall, Matthew; Halpin, Sophie; Hamer, Ansley; Hamidfar, Rebecca; Hammond, Naomi; Hammond, Terese; Han, Lim Yuen; Haniffa, Rashan; Hao, Kok Wei; Hardwick, Hayley; Harrison, Ewen; Harrison, Janet; Harrison, Samuel Bernard Ekow; Hartman, Alan; Hashmi, Junaid; Hayes, Ailbhe; Hays, Leanne; Heerman, Jan; Heggelund, Lars; Hendry, Ross; Hennessy, Martina; Henriquez-Trujillo, Aquiles; Hentzien, Maxime; Hernandez, Diana; Hernandez-Montfort, Jaime; Hershey, Andrew; Hesstvedt, Liv; Hidayah, Astarini; Higgins, Dawn; Higgins, Eibhlin; Higgins, Rupert; Hinchion, Rita; Hinton, Samuel; Hiraiwa, Hiroaki; Hirkani, Haider; Hitoto, Hikombo; Ho, Antonia; Ho, Yi Bin; Hoctin, Alexandre; Hoffmann, Isabelle; Hoh, Wei Han; Hoiting, Oscar; Holt, Rebecca; Holter, Jan Cato; Horby, Peter; Horcajada, Juan Pablo; Hoshino, Koji; Hoshino, Kota; Houas, Ikram; Hough, Catherine; Houltham, Stuart; Hsu, Jimmy Ming-Yang; Hulot, Jean-Sébastien; Huo, Stella; Hurd, Abby; Ijaz, Samreen; Ikram, M. Arfan; Illana, Carlos Cañada; Illes, Hajnal-Gabriela; Imbert, Patrick; Inácio, Hugo; Dominguez, Carmen Infante; Ing, Yun Sii; Iosifidis, Elias; Ippolito, Mariachiara; Irawany, Vera; Isgett, Sarah; Isidoro, Tiago; Ismail, Nadiah; Isnard, Margaux; Itai, Junji; Ito, Asami; Ivulich, Daniel; Jaafar, Danielle; Jaafoura, Salma; Jabot, Julien; Jackson, Clare; Jamieson, Nina; Janes, Victoria; Jaquet, Pierre; Jassat, Waasila; Jaud-Fischer, Coline; Jaureguiberry, Stéphane; Javidfar, Jeffrey; Jaworsky, Denise; Jego, Florence; Jelani, Anilawati Mat; Jenum, Synne; Jimbo-Sotomayor, Ruth; Joe, Ong Yiaw; García, Ruth; Joseph, Cédric; Joseph, Mark; Joshi, Swosti; Jourdain, Mercé; Jouvet, Philippe; Jung, Anna; Jung, Hanna; Juzar, Dafsah; Kafif, Ouifiya; Kaguelidou, Florentia; Kaisbain, Neerusha; Kaleesvran, Thavamany; Kali, Sabina; Kalicinska, Alina; Kalomoiri, Smaragdi; Kamaluddin, Muhammad Aisar Ayadi; Kamaruddin, Zul Amali Che; Kamarudin, Nadiah; Kandamby, Darshana Hewa; Kandel, Chris; Kang, Kong Yeow; Karpayah, Pratap; Karsies, Todd; Kasugai, Daisuke; Kataria, Anant; Katz, Kevin; Kaur, Aasmine; Kay, Christy; Keane, Hannah; Keating, Seán; Kedia, Pulak; Kelly, Andrea; Kelly, Aoife; Kelly, Claire; Kelly, Niamh; Kelly, Sadie; Kelly, Yvelynne; Kelsey, Maeve; Kennedy, Ryan; Kennon, Kalynn; Keomany, Sommay; Kernan, Maeve; Kerroumi, Younes; Keshav, Sharma; Kestelyn, Evelyne; Khalid, Imrana; Khalil, Antoine; Khan, Coralie; Khan, Irfan; Kherajani, Krish; Kho, Michelle; Khoo, Denisa; Khoo, Ryan; Khoo, Saye; Kiat, Khor How; Kida, Yuri; Kiiza, Peter; Granerud, Beathe Kiland; Kildal, Anders Benjamin; Kim, Jae Burm; Kimmoun, Antoine; Kindgen-Milles, Detlef; King, Alexander; Kitamura, Nobuya; Klenerman, Paul; Klont, Rob; Bekken, Gry Kloumann; Knight, Stephen; Kobbe, Robin; Kodippily, Chamira; Vasconcelos, Malte Kohns; Komatsu, Mamoru; Korten, Isaric Collaborator; Kosgei, Caroline; Kpangon, Arsène; Krawczyk, Karolina; Krishnan, Sudhir; Krishnan, Vinothini; Kruglova, Oksana; Kumar, Deepali; Kumar, Ganesh; Vecham, Pavan Kumar; Kuriakose, Dinesh; Kurtzman, Ethan; Kusumastuti, Neurinda Permata; Kutsogiannis, Demetrios; Kutsyna, Galyna; Kyriakoulis, Konstantinos; Hamers, Raph; Lachatre, Marie; Lacoste, Marie; Laffey, John; Lafhej, Nadhem; Lagrange, Marie; Laine, Fabrice; Lairez, Olivier; Lambert, Marc; Lamontagne, François; Langelot-Richard, Marie; Langlois, Vincent; Lantang, Eka Yudha; Lanza, Marina; Laouénan, Cédric; Laribi, Samira; Lariviere, Delphine; Lasry, Stéphane; Lath, Sakshi; Launay, Odile; Laureillard, Didier; Lavie-Badie, Yoan; Law, Andrew; Lawrence, Cassie; Lawrence, Teresa; Le, Minh; Bihan, Clément Le; Bris, Cyril Le; Falher, Georges Le; Fevre, Lucie Le; Hingrat, Quentin Le; Maréchal, Marion Le; Mestre, Soizic Le; Moal, Gwenaël Le; Moing, Vincent Le; Nagard, Hervé Le; Turnier, Paul Le; Leal, Ema; Santos, Marta Leal; Lee, Biing Horng; Lee, Heng Gee; Lee, James; Lee, Jennifer; Lee, Su Hwan; Lee, Todd; Lee, Yi Lin; Leeming, Gary; Lefebvre, Bénédicte; Lefebvre, Laurent; Lefèvre, Benjamin; Legac, Sylvie; Lelievre, Jean-Daniel; Lellouche, François; Lemaignen, Adrien; Lemee, Véronique; Lemeur, Anthony; Lemmink, Gretchen; Lene, Ha Sha; Lennon, Jenny; León, Rafael; Leone, Marc; Leone, Michela; Lescure, François-Xavier; Lesens, Olivier; Lesouhaitier, Mathieu; Lester-Grant, Amy; Letizia, Andrew; Letrou, Sophie; Levy, Bruno; Levy, Yves; Levy-Marchal, Claire; Lewandowska, Katarzyna; L’her, Erwan; Bassi, Gianluigi Li; Liang, Janet; Liegeon, Geoffrey; Lim, Kah Chuan; Lim, Wei Shen; Lima, Chantre; Lina, Bruno; Lina, Lim; Lind, Andreas; Lingad, Maja Katherine; Lingas, Guillaume; Lion-Daolio, Sylvie; Lissauer, Samantha; Liu, Keibun; Livrozet, Marine; Lizotte, Patricia; Loforte, Antonio; Lolong, Navy; Loon, Leong Chee; Lopes, Diogo; Lopez-Colon, Dalia; Lopez-Revilla, Jose; Loschner, Anthony; Loubet, Paul; Loufti, Bouchra; Louis, Guillame; Lourenco, Silvia; Lovelace-Macon, Lara; Low, Lee Lee; Lowik, Marije; Loy, Jia Shyi; Lucet, Jean Christophe; Luna, Carlos; Lungu, Olguta; Luong, Liem; Luque, Nestor; Luton, Dominique; Lwin, Nilar; Lyons, Ruth; Maasikas, Olavi; Mabiala, Oryane; Machado, Moïse; Machado, Sara; Macheda, Gabriel; Madiha, Hashmi; Maglietta, Giuseppe; Mahieu, Rafael; Mahy, Sophie; Maia, Ana Raquel; Maier, Lars; Maillet, Mylène; Maitre, Thomas; Majori, Maria; Malfertheiner, Maximilian; Malik, Nadia; Mallon, Paddy; Maltez, Fernando; Malvy, Denis; Mammi, Patrizia; Manda, Victoria; Mandei, Jose; Mandelbrot, Laurent; Manetta, Frank; Mankikian, Julie; Manning, Edmund; Manuel, Aldric; Marino, Daniel; Marino, Flávio; Markowicz, Samuel; Marques, Ana; Marquis, Catherine; Marsh, Brian; Marshal, Megan; Marshall, John; Martelli, Celina Turchi; Martin, Dori-Ann; Martin, Emily; Martin-Blondel, Guillaume; Martin-Loeches, Ignacio; Martinot, Martin; Martín-Quiros, Alejandro; Martinez, F. Eduardo; Martins, Ana; Martins, João; Martins, Nuno; Rego, Caroline Martins; Martucci, Gennaro; Martynenko, Olga; Marwali, Eva Miranda; Marzukie, Marsilla; Jimenez, Juan Fernado Masa; Maslove, David; Mason, Sabina; Nor, Basri Mat; Matan, Moshe; Mathieu, Daniel; Mattei, Mathieu; Matulevics, Romans; Maulin, Laurence; Maxwell, Michael; Maynar, Javier; Mayxay, Mayfong; Mazzoni, Thierry; Sweeney, Lisa Mc; Mccanny, Peter; Mcarthur, Colin; Mccarthy, Aine; Mccarthy, Anne; Mccloskey, Colin; Mcconnochie, Rachael; Mcdermott, Sherry; Mcdonald, Sarah; Mcelroy, Aine; Mcelwee, Samuel; Mceneany, Victoria; Mcevoy, Natalie; Mcgeer, Allison; Mckay, Chris; Mckeown, Johnny; Mclean, Kenneth; Mcnally, Paul; Mcnicholas, Bairbre; Mcpartlan, Elaine; Meaney, Edel; Mear-Passard, Cécile; Mechlin, Maggie; Mehkri, Omar; Mele, Ferruccio; Melo, Luis; Mendes, Joao Joao; Menkiti, Ogechukwu; Menon, Kusum; Mentré, France; Mentzer, Alexander; Mercier, Emmanuelle; Mercier, Noémie; Merckx, Antoine; Mergeay-Fabre, Mayka; Mergler, Blake; Meschi, Tiziana; Mesquita, António; Meta, Roberta; Metwally, Osama; Meybeck, Agnès; Meyer, Dan; Meynert, Alison; Meysonnier, Vanina; Meziane, Amina; Mezidi, Mehdi; Michelanglei, Céline; Michelet, Isabelle; Mihelis, Efstathia; Mihnovit, Vladislav; Miller, Jennene; Miranda-Maldonado, Hugo; Misnan, Nor Arisah; Mohamed, Nik Nur Eliza; Mohamed, Tahira Jamal; Moin, Asma; Molinos, Elena; Molloy, Brenda; Mone, Mary; Monteiro, Agostinho; Montes, Claudia; Montrucchio, Giorgia; Moore, Sarah; Moore, Shona; Cely, Lina Morales; Moro, Lucia; Morton, Ben; Motherway, Catherine; Motos, Ana; Mouquet, Hugo; Perrot, Clara Mouton; Moyet, Julien; Mudara, Caroline; Muh, Ng Yong; Muhamad, Dzawani; Mullaert, Jimmy; Müller, Fredrik; Müller, Karl Erik; Munblit, Daniel; Murphy, Aisling; Murphy, Lorna; Murris, Marlène; Murthy, Srinivas; Musaab, Himed; Mutti, Carlotta; Muvindi, Himasha; Muyandy, Gugapriyaa; Myrodia, Dimitra Melia; Mohd-Hanafiah, Farah Nadia; Nagpal, Dave; Nagrebetsky, Alex; Narasimhan, Mangala; Narayanan, Nageswaran; Nazerali-Maitland, Alasdair; Neant, Nadège; Neb, Holger; Necsoi, Coca; Nekliudov, Nikita; Nelwan, Erni; Neto, Raul; Neumann, Emily; Ng, Pauline Yeung; Nghi, Anthony; Nguyen, Duc; Choileain, Orna Ni; Leathlobhair, Niamh Ni; Nichol, Alistair; Nitayavardhana, Prompak; Nonas, Stephanie; Noordin, Nurul Amani Mohd; Noret, Marion; Norharizam, Nurul Faten Izzati; Norman, Lisa; North, Anita; Notari, Alessandra; Noursadeghi, Mahdad; Nowicka, Karolina; Nowinski, Adam; Nseir, Saad; Nunez, Jose; Nurnaningsih, Nurnaningsih; Nusantara, Dwi Utomo; Nyamankolly, Elsa; Brien, Fionnuala; Callaghan, Annmarie; O’callaghan, Annmarie; Occhipinti, Giovanna; Oconnor, Derbrenn; O’donnell, Max; Ogston, Tawnya; Ogura, Takayuki; Oh, Tak-Hyuk; O’halloran, Sophie; O’hearn, Katie; Ohshimo, Shinichiro; Oldakowska, Agnieszka; Oliveira, João; Oliveira, Larissa; O’neil, Conar; Ong, David; Ong, Jee Yan; Oosthuyzen, Wilna; Opavsky, Anne; Openshaw, Peter; Orozco-Chamorro, Claudia Milena; Ortoleva, Jamel; Osatnik, Javier; O’shea, Linda; O’sullivan, Miriam; Othman, Siti Zubaidah; Ouamara, Nadia; Ouissa, Rachida; Oziol, Eric; Pagadoy, Maïder; Pages, Justine; Palacios, Amanda; Palmarini, Massimo; Panarello, Giovanna; Panda, Prasan Kumar; Pang, Lai Hui; Panigada, Mauro; Pansu, Nathalie; Papadopoulos, Aurélie; Parducci, Paolo; Oña, Edwin Fernando Paredes; Parke, Rachael; Parker, Melissa; Pasquier, Jérémie; Pastene, Bruno; Patauner, Fabian; Patel, Drashti; Pathmanathan, Mohan Dass; Patrão, Luís; Patricio, Patricia; Patrier, Juliette; Patrizi, Laura; Patterson, Lisa; Paul, Christelle; Paul, Mical; Paulos, Jorge; Paxton, William; Payen, Jean-François; Peake, Sandra; Peek, Giles; Peelman, Florent; Peiffer-Smadja, Nathan; Peigne, Vincent; Pejkovska, Mare; Pelosi, Paolo; Peltan, Ithan; Pereira, Rui; Perez, Daniel; Periel, Luis; Perpoint, Thomas; Pesenti, Antonio; Pestre, Vincent; Petrou, Lenka; Petrovic, Michele; Petrov-Sanchez, Ventzislava; Pettersen, Frank Olav; Peytavin, Gilles; Pharand, Scott; Phonemixay, Ooyanong; Phoutthavong, Soulichanya; Piagnerelli, Michael; Picard, Walter; Picone, Olivier; de Piero, Maria; Pierobon, Carola; Piersma, Djura; Pimentel, Carlos; Pinto, Raquel; Piquard, Valentine; Pires, Catarina; Pironneau, Isabelle; Piroth, Lionel; Pisi, Roberta; Pitaloka, Ayodhia; Piubelli, Chiara; Pius, Riinu; Plantier, Laurent; Png, Hon Shen; Poissy, Julien; Pokeerbux, Ryadh; Pokorska-Spiewak, Maria; Poli, Sergio; Pollakis, Georgios; Ponscarme, Diane; Popielska, Jolanta; Porto, Diego Bastos; Post, Andra-Maris; Postma, Douwe; Povoa, Pedro; Póvoas, Diana; Powis, Jeff; Prapa, Sofia; Praphasiri, Viladeth; Preau, Sébastien; Prebensen, Christian; Preiser, Jean-Charles; Prinssen, Anton; Pritchard, Mark; Priyadarshani, Gamage Dona Dilanthi; Proença, Lucia; Pudota, Sravya; Puéchal, Oriane; Semedi, Bambang Pujo; Puntoni, Matteo; Purcell, Gregory; Quesada, Luisa; Quinones-Cardona, Vilmaris; Quist-Paulsen, Else; Quraishi, Mohammed; Rabaa, Maia; Rabaud, Christian; Rafael, Aldo; Rafiq, Marie; Ragazzo, Gabrielle; Rahardjani, Mutia; Rahman, Ahmad Kashfi Haji Ab; Rahman, Rozanah Abd; Rainieri, Fernando; Ramakrishnan, Nagarajan; Ramalho, José; Ramli, Ahmad Afiq; Rammaert, Blandine; Ramos, Grazielle Viana; Rampello, Anais; Rangappa, Rajavardhan; Ranjan, Ritika; Ranza, Elena; Rapp, Christophe; Rashan, Aasiyah; Rashan, Thalha; Rasmin, Menaldi; Rätsep, Indrek; Rau, Cornelius; Rausa, Francesco; Ravi, Tharmini; Real, Andre; Rebaudet, Stanislas; Redl, Sarah; Reeve, Brenda; Reid, Liadain; Reikvam, Dag Henrik; Reis, Renato; Rello, Jordi; Remppis, Jonathan; Remy, Martine; Ren, Hongru; Renk, Hanna; Resseguier, Anne-Sophie; Revest, Matthieu; Rewa, Oleksa; Reyes, Luis Felipe; Reyes, Tiago; Ribeiro, Maria Ines; Ricchiuto, Antonia; Richardson, David; Richardson, Denise; Richier, Laurent; Ridzuan, Siti Nurul Atikah Ahmad; Riera, Jordi; Rios, Ana; Rishu, Asgar; Rispal, Patrick; Risso, Karine; Nuñez, Maria Angelica Rivera; Rizer, Nicholas; Robba, Chiara; Roberto, André; Robertson, David; Robineau, Olivier; Roche-Campo, Ferran; Rodari, Paola; Rodeia, Simão; Abreu, Julia Rodriguez; Roessler, Bernhard; Roger, Claire; Roger, Pierre-Marie; Roilides, Emmanuel; Rojek, Amanda; Romaru, Juliette; Roncon-Albuquerque, Roberto; Roriz, Mélanie; Rosa-Calatrava, Manuel; Rose, Michael; Rosenberger, Dorothea; Rossanese, Andrea; Rossetti, Matteo; Rossi, Sandra; Rossignol, Bénédicte; Rossignol, Patrick; Rousset, Stella; Roy, Carine; Roze, Benoît; Rusmawatiningtyas, Desy; Russell, Clark; Ryan, Maeve; Ryan, Maria; Ryckaert, Steffi; Holten, Aleksander Rygh; Saba, Isabela; Sacchelli, Luca; Sadat, Musharaf; Sahraei, Valla; Saidani, Nadia; Saint-Gilles, Maximilien; Sakiyalak, Pranya; Salazar, Leonardo; Sales, Gabriele; Sallaberry, Stéphane; Gandonniere, Charlotte Salmon; Salvator, Hélène; Sanchez, Olivier; Sanchez-Miralles, Angel; Sancho-Shimizu, Vanessa; Sandhu, Gyan; Sandhu, Zulfiqar; Sandrine, Pierre-François; Sandulescu, Oana; Santos, Marlene; Sarfo-Mensah, Shirley; Banheiro, Bruno Sarmento; Sarmiento, Iam Claire E.; Sarton, Benjamine; Satya, Ankana; Satyapriya, Sree; Satyawati, Rumaisah; Saviciute, Egle; Savvidou, Parthena; Saw, Yen Tsen; Schaffer, Justin; Schermer, Tjard; Scherpereel, Arnaud; Schneider, Marion; Schroll, Stephan; Schwameis, Michael; Schwartz, Gary; Scicluna, Brendan; Scott, Janet; Scott-Brown, James; Sedillot, Nicholas; Seitz, Tamara; Selvarajoo, Mageswari; Semaille, Caroline; Semple, Malcolm; Senian, Rasidah Bt; Senneville, Eric; Sepulveda, Claudia; Sequeira, Filipa; Sequeira, Tânia; Neto, Ary Serpa; Shadowitz, Ellen; Shahidan, Syamin Asyraf; Shamsah, Mohammad; Shankar, Anuraj; Sharjeel, Shaikh; Sharma, Pratima; Shaw, Catherine; Shaw, Victoria; Shetty, Rajesh Mohan; Shetty, Rohan; Shi, Haixia; Shiban, Nisreen; Shiekh, Mohiuddin; Shiga, Takuya; Shime, Nobuaki; Shimizu, Hiroaki; Shimizu, Keiki; Shrapnel, Sally; Shum, Hoi Ping; Mohammed, Nassima Si; Siang, Ng Yong; Sibiude, Jeanne; Sibounheuang, Bountoy; Siddiqui, Atif; Sigfrid, Louise; Sillaots, Piret; Silva, Catarina; Silva, Maria Joao; Silva, Rogério; Heng, Benedict Sim Lim; Sin, Wai Ching; Sinatti, Dario; Singh, Budha Charan; Singh, Punam; Sitompul, Pompini Agustina; Sivam, Karisha; Skogen, Vegard; Smith, Sue; Smood, Benjamin; Smyth, Coilin; Smyth, Michelle; Snacken, Morgane; So, Dominic; Soh, Tze Vee; Solomon, Joshua; Solomon, Tom; Somers, Emily; Sommet, Agnès; Song, Myung Jin; Song, Rima; Song, Tae; Chia, Jack Song; Sonntagbauer, Michael; Soom, Azlan Mat; Sotto, Albert; Soum, Edouard; Sousa, Ana Chora; Sousa, Marta; Uva, Maria Sousa; Souza-Dantas, Vicente; Sperry, Alexandra; Spinuzza, Elisabetta; Darshana, B.; Sriskandan, Shiranee; Stabler, Sarah; Staudinger, Thomas; Stecher, Stephanie-Susanne; Steinsvik, Trude; Stienstra, Ymkje; Stiksrud, Birgitte; Stolz, Eva; Stone, Amy; Streinu-Cercel, Adrian; Streinu-Cercel, Anca; Stuart, Ami; Stuart, David; Su, Richa; Subekti, Decy; Suen, Gabriel; Suen, Jacky; Sultana, Asfia; Summers, Charlotte; Supic, Dubravka; Suppiah, Deepashankari; Surovcová, Magdalena; Suwarti, Atie; Svistunov, Andrey; Syahrin, Sarah; Syrigos, Konstantinos; Sztajnbok, Jaques; Szuldrzynski, Konstanty; Tabrizi, Shirin; Taccone, Fabio; Tagherset, Lysa; Taib, Shahdattul Mawarni; Talarek, Ewa; Taleb, Sara; Talsma, Jelmer; Tamisier, Renaud; Tampubolon, Maria Lawrensia; Tan, Kim Keat; Tan, Le Van; Tan, Yan Chyi; Tanaka, Clarice; Tanaka, Hiroyuki; Tanaka, Taku; Taniguchi, Hayato; Tardivon, Coralie; Tattevin, Pierre; Taufik, M Azhari; Tawfik, Hassan; Tedder, Richard; Tee, Tze Yuan; Teixeira, João; Tejada, Sofia; Tellier, Marie-Capucine; Teoh, Sze Kye; Teotonio, Vanessa; Téoulé, François; Terpstra, Pleun; Terrier, Olivier; Terzi, Nicolas; Tessier-Grenier, Hubert; Tey, Adrian; Thabit, Alif Adlan Mohd; Tham, Zhang Duan; Thangavelu, Suvintheran; Thibault, Vincent; Thiberville, Simon-Djamel; Thill, Benoît; Thirumanickam, Jananee; Thompson, Shaun; Thomson, David; Thomson, Emma; Thurai, Surain Raaj Thanga; Thuy, Duong Bich; Thwaites, Ryan; Ticinesi, Andrea; Tierney, Paul; Tieroshyn, Vadim; Timashev, Peter; Timsit, Jean-François; Tissot, Noémie; Toh, Jordan Zhien Yang; 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Eoin; Wham, Murray; Whelan, Bryan; Wicky, Paul Henri; Wiedemann, Aurélie; Wijaya, Surya Otto; Wille, Keith; Willems, Sue; Williams, Patricia; Williams, Virginie; Wils, Evert-Jan; Yiu, Ng Wing; Wong, Calvin; Wong, Teck Fung; Wong, Yew Sing; Wright, Natalie; Xian, Gan Ee; Xian, Lim Saio; Xuan, Kuan Pei; Xynogalas, Ioannis; Yacoub, Sophie; Yakop, Siti Rohani Binti Mohd; Yamazaki, Masaki; Yarad, Elizabeth; Yazdanpanah, Yazdan; Hing, Nicholas Yee Liang; Yelnik, Cécile; Yeoh, Chian Hui; Yerkovich, Stephanie; Yiaye, Touxiong; Yokoyama, Toshiki; Yonis, Hodane; Yousif, Obada; Yuliarto, Saptadi; Zaaqoq, Akram; Zabbe, Marion; Zabert, Gustavo; Zacharowski, Kai; Zahid, Masliza; Zahran, Maram; Zaidan, Nor Zaila Binti; Zambon, Maria; Zambrano, Miguel; Zanella, Alberto; Zawadka, Konrad; Zaynah, Nurul; Zayyad, Hiba; Zoufaly, Alexander; Zucman, David |
| Contributors: |
University of Oxford; Human genetics of infectious diseases: Complex predisposition (Equipe Inserm U1163); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); French COVID cohort study group; Department of Mathematics and Statistics; Wichita State University; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Université Grenoble Alpes (UGA); Hypoxie et PhysioPathologie (HP2); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); ARN bactériens et médecine (BRM); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); Institut de recherche en santé, environnement et travail (Irset); Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes (Biosit : Biologie - Santé - Innovation Technologique); M. Mesinovic appreciates the support of the EPSRC Center for Doctoral Training in Health Data Science (EP/S02428X/1) and the Rhodes Trust.This work was made possible by the UK Foreign, Commonwealth and Development Office and Wellcome 215091/Z/18/Z, 222410/Z/21/Z, 225288/Z/22/Z and 220757/Z/20/Z; the Bill & Melinda Gates Foundation OPP1209135; the philanthropic support of the donors to the University of Oxford’s COVID-19 Research Response Fund (0009109); CIHR Coronavirus Rapid Research Funding Opportunity OV2170359 and the coordination in Canada by Sunnybrook Research Institute; endorsement of the Irish Critical Care-Clinical Trials Group, co-ordination in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funding by the Health Research Board of Ireland CTN-2014-12; the Rapid European COVID-19 Emergency Response research (RECOVER) H2020 project 101003589 and European Clinical Research Alliance on Infectious Diseases (ECRAID) 965313; the COVID clinical management team, AIIMS, Rishikesh, India; the COVID-19 Clinical Management team, Manipal Hospital Whitefield, Bengaluru, India; Cambridge NIHR Biomedical Research Centre; the dedication and hard work of the Groote Schuur Hospital Covid ICU Team and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; the Liverpool School of Tropical Medicine and the University of Oxford; the dedication and hard work of the Norwegian SARS-CoV-2 study team and the Research Council of Norway grant no 312780, and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; Imperial NIHR Biomedical Research Centre; the Comprehensive Local Research Networks (CLRNs) of which PJMO is an NIHR Senior Investigator (NIHR201385); Innovative Medicines Initiative Joint Undertaking under Grant Agreement No. 115523 COMBACTE, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007- 2013) and EFPIA companies, in-kind contribution; Stiftungsfonds zur Förderung der Bekämpfung der Tuberkulose und anderer Lungenkrankheiten of the City of Vienna, Project Number: APCOV22BGM; Italian Ministry of Health “Fondi Ricerca corrente-L1P6” to IRCCS Ospedale Sacro Cuore-Don Calabria; Australian Department of Health grant (3273191); Gender Equity Strategic Fund at University of Queensland, Artificial Intelligence for Pandemics (A14PAN) at University of Queensland, the Australian Research Council Centre of Excellence for Engineered Quantum Systems (EQUS, CE170100009), the Prince Charles Hospital Foundation, Australia; grants from Instituto de Salud Carlos III, Ministerio de Ciencia, Spain; Brazil, National Council for Scientific and Technological Development Scholarship number 303953/2018-7; the Firland Foundation, Shoreline, Washington, USA; the French COVID cohort (NCT04262921) is sponsored by INSERM and is funded by the REACTing (REsearch & ACtion emergING infectious diseases) consortium and by a grant of the French Ministry of Health (PHRC n20-0424); a grant from foundation Bevordering Onderzoek Franciscus; the South Eastern Norway Health Authority and the Research Council of Norway; Institute for Clinical Research (ICR), National Institutes of Health (NIH) supported by the Ministry of Health Malaysia; preparedness work conducted by the Short Period Incidence Study of Severe Acute Respiratory Infection; the U.S. DoD Armed Forces Health Surveillance Division, Global Emerging Infectious Diseases Branch to the U.S Naval Medical Research Unit No. TWO (NAMRU-2) (Work Unit #: P0153_21_N2). These authors would like to thank Vysnova Partners, Inc. for the management of this research project. The Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit is funded by the Wellcome Trust. This work uses data provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The data used for this research were obtained from ISARIC4C. We are extremely grateful to the 2648 frontline NHS clinical and research staff and volunteer medical students who collected these data in challenging circumstances; and the generosity of the patients and their families for their individual contributions in these difficult times. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision was supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; grant MC_PC_19059), and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), (award 200907), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Liverpool Experimental Cancer Medicine Centre (grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (award ISBRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. We also acknowledge the support of Jeremy J Farrar and Nahoko Shindo.; ISARIC Council Meeting Contributors : Tamuna Akhvlediani, Derek Angus, Ken Baillie, Scott Berry, Lucille Blumberg, Fernando Bozza, Stephen Brett, Abdullah Brooks, Caroline Brown, Roberto Bruzzone, Gail Carson, Jean-Daniel Chiche, Menno de Jong, Xavier de Lamballerie, Arjen Dondorp, Dean Everett, Jeremy Farrar, Zhancheng Gao, Herman Goossens, Fred Hayden, Jean-Michel Heraud, Tran Tinh, Raul Isturiz, Paul Kellam, Keith Klugman, Dan Korbel, Tatia Kuchuloria, David Lalloo, Trudie Lang, Matthew Lim, Le Thi, Kajsa-Stina Magnusson, Kathryn Maitland, John Marshall, Shelly McNeil, Laura Merson, Manuel Morillas, Bernadette Murgue, Lois Nicholas, Piero Olliaro, Peter Openshaw, Malik Peiris, Garyphallia Poulakou, Robert Read, Jordi Rello, Gernot Rohde, Cathy Roth, Kathy Rowan, Guillermo Ruiz-Palacios, Calum Semple, Nikki Shindo, Yuelong Shu, Marilda Siqueira, Dat Tran, Tim Uyeki, Guy Vernet, Timothy Walsh, Steve Webb, Marcel Wolbers. |
| Source: |
ISSN: 2045-2322. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2024 |
| Subject Terms: |
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41598-024-63212-7 |
| Availability: |
https://hal.science/hal-04831133; https://hal.science/hal-04831133v2/document; https://hal.science/hal-04831133v2/file/s41598-024-63212-7-2.pdf; https://doi.org/10.1038/s41598-024-63212-7 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.3C794EAF |
| Database: |
BASE |