| Title: |
Which definitions for MRI sacroiliac joint lesions predict the diagnosis of early axial spondyloarthritis best?: A 2-year follow-up in the SPACE cohort |
| Authors: |
Bruin, L.J.E. de; Marques, M.L.; Lunteren, M. van; Hooge, M. de; Reijnierse, M.; Exarchou, S.; Berg, I.J.; Ramonda, R.; Landewé, R.; Gaalen, F.A. van; Heijde, D. van der; Ramiro, S. |
| Source: |
RMD Open: Rheumatic and Musculoskeletal Diseases |
| Publication Year: |
2026 |
| Collection: |
Leiden Repository (Leiden University) |
| Subject Terms: |
Axial Spondyloarthritis; Sensitivity and Specificity; Magnetic Resonance Imaging |
| Description: |
Background: The Leiden group and the Assessment of Spondyloarthritis International Society (ASAS)-MRI study group have proposed definitions for structural (SL) and active (AL) lesions typical for axial spondyloarthritis (axSpA) on MRI of the sacroiliac joints (MRI-SIJ). Objectives: To analyse the predictive validity of proposed SL and AL MRI-SIJ definitions in early axSpA and compare proposed AL with the current ASAS-MRI-SIJ+ definition. Methods: Patients with chronic back pain (= 95%. Results: Among 643 patients (52% axSpA), SL were infrequent (2%-14%). All Leiden and most MRI study group SL definitions met the validation threshold, except for 'erosion in >= 2 consecutive slices' and the overall MRI study group definition (PPV |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/1887/4300376 |
| DOI: |
10.1136/rmdopen-2025-006425 |
| Availability: |
https://hdl.handle.net/1887/4300376; https://doi.org/10.1136/rmdopen-2025-006425 |
| Accession Number: |
edsbas.3CA85EE2 |
| Database: |
BASE |