Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.
| Title: | Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms. |
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| Authors: | Fernandez-Twinn, Denise S; Alfaradhi, Maria Z; Martin-Gronert, Malgorzata S; Duque-Guimaraes, Daniella E; Piekarz, Ana; Ferland-McCollough, David; Bushell, Martin; Ozanne, Susan E |
| Publisher Information: | Elsevier; //doi.org/10.1016/j.molmet.2014.01.007 |
| Publication Year: | 2014 |
| Collection: | Apollo - University of Cambridge Repository |
| Subject Terms: | Adipose tissue; DEXA; dual energy X-ray absorptiometry; Hyperinsulinemia; IRS1; IRβ; insulin receptor-beta; Maternal obesity; PI3K; phosphotidylinositol 3-kinase; UTR; untranslated region; miRNA; microRNA; microRNAs |
| Description: | We determined the effects of maternal diet-induced obesity on offspring adipose tissue insulin signalling and miRNA expression in the aetiology of insulin resistance in later life. Although body composition and glucose tolerance of 8-week-old male offspring of obese dams were not dysregulated, serum insulin was significantly (p |
| Document Type: | article in journal/newspaper |
| File Description: | Electronic-eCollection; application/pdf |
| Language: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/302793 |
| DOI: | 10.17863/CAM.49868 |
| Availability: | https://www.repository.cam.ac.uk/handle/1810/302793; https://doi.org/10.17863/CAM.49868 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.3CB48D94 |
| Database: | BASE |