| Title: |
High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| Authors: |
De Felice, Francesca; Clementi, Ilaria; Converti, Valeria; Crocetti, Daniele; Sapienza, Paolo; Bulzonetti, Nadia; Richard, Sassun; Musio, Daniela; Mingoli, Andrea; Tombolini, Vincenzo |
| Contributors: |
De Felice, Francesca; Clementi, Ilaria; Converti, Valeria; Crocetti, Daniele; Sapienza, Paolo; Bulzonetti, Nadia; Richard, Sassun; Musio, Daniela; Mingoli, Andrea; Tombolini, Vincenzo |
| Publisher Information: |
Elsevier; STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
anal canal cancer; HPV; high-resolution anoscopy; radiotherapy; response; salvage surgery; treatment failure |
| Description: |
Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era.Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patients with anal canal malignant lesions.Results: HRA features could be important to assess the effect of CRT and a risk stratification system should be introduced in clinical practice to better allocate therapeutic interventions.Conclusion: To our knowledge this is the first proposal for HRA findings in anal canal cancer after definitive CRT. We believe that a risk score can be useful to estimate the risk of treatment failure (in term of persistence disease and/or recurrence) and its clinical relevance should not to be underestimated. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36444781; info:eu-repo/semantics/altIdentifier/wos/WOS:000928237800001; volume:27; numberofpages:3; journal:TRANSLATIONAL ONCOLOGY; https://hdl.handle.net/11573/1676462 |
| DOI: |
10.1016/j.tranon.2022.101590 |
| Availability: |
https://hdl.handle.net/11573/1676462; https://doi.org/10.1016/j.tranon.2022.101590 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.3CC3CD87 |
| Database: |
BASE |