| Title: |
Exploring the Role of Krebs von den Lungen-6 in Severe to Critical COVID-19 Patients |
| Authors: |
D'Agnano V.; Scialo F.; Perna F.; Atripaldi L.; Sanduzzi S.; Allocca V.; Vitale M.; Pastore L.; Bianco A.; Perrotta F. |
| Contributors: |
D'Agnano, V.; Scialo, F.; Perna, F.; Atripaldi, L.; Sanduzzi, S.; Allocca, V.; Vitale, M.; Pastore, L.; Bianco, A.; Perrotta, F. |
| Publication Year: |
2022 |
| Collection: |
Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| Subject Terms: |
COVID-19; Krebs von den Lungen-6; lung ultrasound score; SARS-CoV-2 |
| Description: |
COVID-19 encompasses a broad spectrum of clinical conditions caused by SARS-CoV-2 infection. More severe cases experience acute respiratory and/or multiorgan failure. KL-6 is a glycoprotein expressed mainly from type II alveolar cells with pro-fibrotic properties. Serum KL-6 concentrations have been found in patients with COVID-19. However, the relevance of KL-6 in patients with severe and critical COVID-19 has not been fully elucidated. Methods: Retrospective data from consecutive severe to critical COVID-19 patients were collected at UOC Clinica Pnuemologica “Vanvitelli”, A.O. dei Colli, Naples, Italy. The study included patients with a positive rhinopharyngeal swab for SARS-CoV-2 RNA with severe or critical COVID-19. Results: Among 87 patients, 24 had poor outcomes. The median KL-6 value in survivors was significantly lower when compared with dead or intubated patients (530 U/mL versus 1069 U/mL p < 0.001). KL-6 was correlated with body mass index (BMI) (r: 0.279, p: 0.009), lung ultrasound score (LUS) (r: 0.429, p < 0.001), Chung Score (r: 0.390, p < 0.001). KL-6 was associated with the risk of death or oro-tracheal intubation (IOT) after adjusting for gender, BMI, Charlson Index, Chung Score, and PaO2/FIO2 (OR 1.003 95% CI 1.001–1.004, p < 0.001). Serum KL-6 value of 968 has a sensitivity of 79.2%, specificity of 87.1%, PPV 70.4%, NPV 91.5%, AUC: O.85 for risk of death or IOT. Conclusions: The presented research highlights the relevance of serum KL-6 in severe to critical COVID-19 patients in predicting the risk of death or IOT. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36013321; info:eu-repo/semantics/altIdentifier/wos/WOS:000846533500001; volume:12; issue:8; firstpage:1141; journal:LIFE; https://hdl.handle.net/11591/477570 |
| DOI: |
10.3390/life12081141 |
| Availability: |
https://hdl.handle.net/11591/477570; https://doi.org/10.3390/life12081141 |
| Accession Number: |
edsbas.3CD41767 |
| Database: |
BASE |