| Title: |
Phytochemical analysis and In vitro antileukemic activity of alkaloid-enriched extracts from Vinca sardoa (Stearn) Pignatti |
| Authors: |
Daniela De Vita; Claudio Frezza; Fabio Sciubba; Chiara Toniolo; Camilla Badiali; Rita Petrucci; Martina Bortolami; Paola Di Matteo; Daniele Rocco; Annarita Stringaro; Marisa Colone; Andrea Maxia; Maria Teresa Petrucci; Mauro Serafini; Sebastiano Foddai |
| Contributors: |
DE VITA, Daniela; Frezza, Claudio; Sciubba, Fabio; Toniolo, Chiara; Badiali, Camilla; Petrucci, Rita; Bortolami, Martina; DI MATTEO, Paola; Rocco, Daniele; Stringaro, Annarita; Colone, Marisa; Maxia, Andrea; Petrucci, MARIA TERESA; Serafini, Mauro; Foddai, Sebastiano |
| Publisher Information: |
MDPI; Basel |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
Vinca sardoa (Stearn) Pignatti; Vinca difformis subsp. sardoa Stearn; Sardinian periwinkle; alkaloid; antileukemic activity; ESI-MS/MS characterization; HPLC-PDA-ESI-MS analysis |
| Description: |
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 g/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:001045668500001; volume:28; issue:15; firstpage:1; lastpage:10; numberofpages:10; journal:MOLECULES; https://hdl.handle.net/11573/1686128 |
| DOI: |
10.3390/molecules28155639 |
| Availability: |
https://hdl.handle.net/11573/1686128; https://doi.org/10.3390/molecules28155639 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.3CE1B4A7 |
| Database: |
BASE |