| Title: |
Psychological outcomes of dementia risk estimation in MCI patients: Results from the PreDADQoL project |
| Authors: |
Rostamzadeh, Ayda; Kalthegener, Franziska; Schwegler, Carolin; Romotzky, Vanessa; Gil-Navarro, Silvia; Rosende-Roca, Maitée; Ortega, Gemma; Canabate, Pilar; Moreno, Mariola; Maier, Franziska; Zeyen, Philip; Schild, Ann-Katrin; Meiberth, Dix; Sannemann, Lena; Bohr, Lara; Schmitz-Luhn, Björn; Boada, Mercè; Woopen, Christiane; Jessen, Frank |
| Source: |
Alzheimer's & Dementia ; 20 ; 11 ; 7635-7656 |
| Publisher Information: |
USA |
| Publication Year: |
2025 |
| Collection: |
SSOAR - Social Science Open Access Repository |
| Subject Terms: |
Medizin und Gesundheit; Medicine and health; Alzheimer's disease; biomarker; close other; dementia risk; disclosure; mild cognitive impairment; satisfaction with life; Deutsche Version der Positive and Negative Affect Schedule PANAS (GESIS Panel) (ZIS 242; doi:10.6102/zis242); Medizin; Sozialmedizin; Medicine; Social Medicine; Demenz; Depression; Lebensqualität; Angst; Beratung; Problembewältigung; dementia; quality of life; anxiety; counseling; coping |
| Description: |
Introduction: Understanding the impact of biomarker-based dementia risk estimation in people with mild cognitive impairment (MCI) and their care partners is critical for patient care. Methods: MCI patients and study partners were counseled on Alzheimer's disease (AD) biomarker and dementia risk was disclosed. Data on mood, quality of life (QoL), and satisfaction with life (SwL) were obtained 1 week and 3 months after disclosure. Results: Seventy-five dyads were enrolled, and two-thirds of the patients opted for biomarker testing. None of the participants experienced clinically relevant depression or anxiety after disclosure. All dyads reported moderate to high QoL and SwL throughout the study. Patients reported more subthreshold depressive symptoms 1 week and lower QoL and SwL 3 months after disclosure. In patients, depression (odds ratio OR: 0.76) and anxiety (OR: 0.81) were significant predictors for the decision against biomarker testing. Discussion: No major psychological harm is to be expected in MCI patients and care partners after dementia risk disclosure. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
https://www.ssoar.info/ssoar/handle/document/103415; https://doi.org/10.1002/alz.14226 |
| DOI: |
10.1002/alz.14226 |
| Availability: |
https://www.ssoar.info/ssoar/handle/document/103415; http://nbn-resolving.org/urn:nbn:de:0168-ssoar-103415-3; https://doi.org/10.1002/alz.14226 |
| Rights: |
Creative Commons - Namensnennung, Nicht kommerz., Keine Bearbeitung 4.0 ; Creative Commons - Attribution-Noncommercial-No Derivative Works 4.0 |
| Accession Number: |
edsbas.3CF2E74E |
| Database: |
BASE |