| Title: |
Regimens to treat multidrug-resistant tuberculosis: past, present and future perspectives. |
| Authors: |
Pontali, Emanuele; Raviglione, Mario C; Migliori, Giovanni Battista; and the writing group members of the Global TB Network Clinical |
| Publisher Information: |
EUROPEAN RESPIRATORY SOC JOURNALS LTD |
| Publication Year: |
2019 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Over the past few decades, treatment of multidrug-resistant (MDR)/extensively drug-resistant (XDR) tuberculosis (TB) has been challenging because of its prolonged duration (up to 20-24 months), toxicity, costs and sub-optimal outcomes.After over 40 years of neglect, two new drugs (bedaquiline and delamanid) have been made available to manage difficult-to-treat MDR-/XDR-TB cases. World Health Organization (WHO) guidelines published in March 2019 endorsed the possibility of treating MDR-TB patients with a full oral regimen, following previous guidelines published in 2016 which launched a shorter regimen lasting 9-10 months.The objectives of this article are to review the main achievements in MDR-TB treatment through the description of the existing WHO strategies, to discuss the main ongoing trials and to shed light on potential future scenarios and revised definitions necessary to manage drug-resistant TB. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0905-9180 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4654485/1/190035.full.pdf; Pontali, Emanuele; Raviglione, Mario C; Migliori, Giovanni BattistaORCID logo; and and the writing group members of the Global TB Network Clinical (2019) Regimens to treat multidrug-resistant tuberculosis: past, present and future perspectives. EUROPEAN RESPIRATORY REVIEW, 28 (152). p. 190035. ISSN 0905-9180 DOI:10.1183/16000617.0035-2019 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4654485/; https://researchonline.lshtm.ac.uk/id/eprint/4654485/1/190035.full.pdf |
| Rights: |
cc_by_nc |
| Accession Number: |
edsbas.3D5A1D8 |
| Database: |
BASE |