| Title: |
Breastfeeding after breast cancer in young BRCA carriers |
| Authors: |
Blondeaux, E; Delucchi, V; Mariamidze, E; Bernstein-Molho, R; Frank, S; Ferrari, A; Linn, S; Kim, HJ; Agostinetto, E; Paluch-Shimon, S; Cortesi, L; Di Meglio, A; Balmana, J; Yerushalmi, R; Rodriguez-Wallberg, KA; Renaud, T; Cui, W; Moore, HCF; Wong, SM; Pogoda, K; Lustberg, M; Phillips, KA; Han, S; Puglisi, F; Vernieri, C; Bajpai, J; Sonnenblick, A; Rousset-Jablonski, C; De Marchis, L; De Giorgi, U; Bianchini, G; Texeira, L; Duhoux, FP; Villarreal-Garza, C; Sini, V; Fruscio, R; Del Mastro, L; Demeestere, I; Azim, HA; Peccatori, FA; Partridge, AH; Lambertini, M |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: We investigated safety of breastfeeding after breast cancer in patients carrying germline BRCA pathogenic or likely pathogenic variants. METHODS: This was an international, multicenter, hospital-based, retrospective cohort study including BRCA carriers diagnosed with stage I-III invasive breast cancer at age 40 years or younger between January 2000 and December 2020 (NCT03673306). Locoregional recurrences and/or contralateral breast cancers, disease-free survival (DFS), and overall survival (OS) were compared between patients who breastfed after delivery and those who did not. RESULTS: Among 4732 patients included from 78 centers worldwide, 659 had a pregnancy after breast cancer diagnosis, of whom 474 delivered a child. After excluding patients with uptake of bilateral risk-reducing mastectomy prior to delivery (n = 225) or unknown breastfeeding status (n = 71), 110 (61.8%) breastfed (median duration 5 months) and 68 (38.2%) did not breastfeed. Compared to patients in the no breastfeeding group, those who breastfed were more frequently nulliparous at breast cancer diagnosis (61.8% vs 45.6%) and did not report prior smoking habit (71.8% vs 57.4%). After a median follow-up of 7.0 years following delivery, 7-year cumulative incidence of locoregional recurrences and/or contralateral breast cancers was 29% in the breastfeeding group and 36% in the no breastfeeding group (adjusted subdistribution hazard ratio [HR] = 1.08, 95% CI = 0.57 to 2.06). No difference in DFS (adjusted hazard ratio [aHR] = 0.83, 95% CI = 0.49 to 1.41) nor in OS (aHR = 1.32, 95% CI = 0.31 to 5.66) was observed. CONCLUSIONS: Breastfeeding did not appear to be associated with a higher risk of developing locoregional recurrences or contralateral breast cancers, emphasizing the possibility of achieving a balance between maternal and infant needs without compromising oncological safety. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0027-8874 |
| Relation: |
pii: 8191277; https://hdl.handle.net/11343/361872 |
| Availability: |
https://hdl.handle.net/11343/361872 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0 ; CC BY-NC-ND |
| Accession Number: |
edsbas.3D9CE07A |
| Database: |
BASE |