Metabolic disorders across hepatocellular carcinoma in Italy
| Title: | Metabolic disorders across hepatocellular carcinoma in Italy |
|---|---|
| Authors: | Morisco F.; Guarino M.; Valvano M. R.; Auriemma F.; Farinati F.; Giannini E. G.; Ciccarese F.; Tovoli F.; Rapaccini G. L.; Di Marco M.; Caturelli E.; Zoli M.; Borzio F.; Sacco R.; Cabibbo G.; Felder M.; Benvengu L.; Gasbarrini A.; Svegliati Baroni G.; Foschi F. G.; Biasini E.; Masotto A.; Virdone R.; Marra F.; Caporaso N.; Trevisani F.; Sessa A.; Marafatto F.; Peserico G.; Pozzan C.; Brunacci M.; Moscatelli A.; Pellegatta G.; Savarino V.; Del Poggio P.; Olmi S.; de Matthaeis N.; Balsamo C.; Vavassori E.; Roselli P.; Lauria V.; Pelecca G.; Mismas V.; Rossi M.; Attardo S.; Cavani G.; Mega A.; Rinninella E.; Ortolani A.; Bevilacqua V.; Chiara Dall'Aglio A.; Ercolani G.; Fiorini E.; Casadei Gardini A.; Lanzi A.; Mirici Cappa F.; Missale G.; Porro E.; Marchetti F.; Valerio M.; Affronti A.; Orlando E.; Rosa Barcellona M.; Aburas S.; Dragoni G.; Campani C.; Biselli M.; Bucci L.; Caraceni P.; Cucchetti A.; Domenicali M.; Garuti F.; Gramenzi A.; Magalotti D.; Serra C.; Granito A.; Negrini G.; Napoli L.; Piscaglia F. |
| Contributors: | Morisco, F.; Guarino, M.; Valvano, M. R.; Auriemma, F.; Farinati, F.; Giannini, E. G.; Ciccarese, F.; Tovoli, F.; Rapaccini, G. L.; Di Marco, M.; Caturelli, E.; Zoli, M.; Borzio, F.; Sacco, R.; Cabibbo, G.; Felder, M.; Benvengu, L.; Gasbarrini, A.; Svegliati Baroni, G.; Foschi, F. G.; Biasini, E.; Masotto, A.; Virdone, R.; Marra, F.; Caporaso, N.; Trevisani, F.; Sessa, A.; Marafatto, F.; Peserico, G.; Pozzan, C.; Brunacci, M.; Moscatelli, A.; Pellegatta, G.; Savarino, V.; Del Poggio, P.; Olmi, S.; de Matthaeis, N.; Balsamo, C.; Vavassori, E.; Roselli, P.; Lauria, V.; Pelecca, G.; Mismas, V.; Rossi, M.; Attardo, S.; Cavani, G.; Mega, A.; Rinninella, E.; Ortolani, A.; Bevilacqua, V.; Chiara Dall'Aglio, A.; Ercolani, G.; Fiorini, E.; Casadei Gardini, A.; Lanzi, A.; Mirici Cappa, F.; Missale, G.; Porro, E.; Marchetti, F.; Valerio, M.; Affronti, A.; Orlando, E.; Rosa Barcellona, M.; Aburas, S.; Dragoni, G.; Campani, C.; Biselli, M.; Bucci, L.; Caraceni, P.; Cucchetti, A.; Domenicali, M.; Garuti, F.; Gramenzi, A.; Magalotti, D.; Serra, C.; Granito, A.; Negrini, G.; Napoli, L.; Piscaglia, F. |
| Publisher Information: | Blackwell Publishing Ltd |
| Publication Year: | 2018 |
| Subject Terms: | diabetes; hepatocellular carcinoma; metabolic syndrome; obesity; Aged; Carcinoma; Hepatocellular; Databases; Factual; Diabetes Mellitus; Female; Humans; Italy; Liver Neoplasms; Male; Metabolic Diseases; Middle Aged; Multivariate Analysis; Neoplasm Staging; Retrospective Studies; Risk Factors; Survival Analysis |
| Description: | Background: Metabolic disorders are well-known risk factors for HCC. Conversely, their impact on the natural history of HCC is not established. This study aimed at evaluating the impact of metabolic disorders on clinical features, treatment and survival of HCC patients regardless of its aetiology. Methods: We analysed the ITA.LI.CA database regarding 839 HCC patients prospectively collected. The following metabolic features were analysed: BMI, diabetes, arterial hypertension, hypercholesterolaemia and hypertriglyceridaemia. According to these features, patients were divided into 3 groups: 0-1, 2 and 3-5 metabolic features. Results: As compared with patients with 0-1 metabolic features, patients with 3-5 features showed lower percentage of HCC diagnosis on surveillance (P=.021), larger tumours (P=.038), better liver function (higher percentage of Child-Pugh class A [P=.007] and MELD |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000448181200017; volume:38; issue:11; firstpage:2028; lastpage:2039; numberofpages:12; journal:LIVER INTERNATIONAL; https://hdl.handle.net/20.500.11768/125293 |
| DOI: | 10.1111/liv.13877 |
| Availability: | https://hdl.handle.net/20.500.11768/125293; https://doi.org/10.1111/liv.13877 |
| Accession Number: | edsbas.3DFB81FE |
| Database: | BASE |