| Title: |
Rivastigmine for dementia associated with Parkinson's disease |
| Authors: |
Emre, M.; Aarsland, D.; Albanese, A.; Byrne, E.J.; Deuschl, G.; De Deyn, P.P.; Durif, F.; Kulisevsky, J.; van Laar, T.; Lees, A.; Poewe, W.; Robillard, A.; Rosa, M.M.; Wolters, E.; Quarg, P.; Tekin, S.; Lane, R. |
| Source: |
New England Journal of Medicine , 351 (24) pp. 2509-2518. (2004) |
| Publication Year: |
2004 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Background: Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of the dual cholinesterase inhibitor rivastigmine in such patients. Methods: Patients in whom mild-to-moderate dementia developed at least 2 years after they received a clinical diagnosis of Parkinson's disease were randomly assigned to receive placebo or 3 to 12 mg of rivastigmine per day for 24 weeks. Primary efficacy variables were the scores for the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog) and Alzheimer's Disease Cooperative Study–Clinician's Global Impression of Change (ADCS-CGIC). Secondary clinical outcomes were the scores for the Alzheimer's Disease Cooperative Study–Activities of Daily Living, the 10-item Neuropsychiatric Inventory, the Mini–Mental State Examination, Cognitive Drug Research power of attention tests, the Verbal Fluency test, and the Ten Point Clock-Drawing test. Results: A total of 541 patients were enrolled, and 410 completed the study. The outcomes were better among patients treated with rivastigmine than among those who received placebo; however, the differences between these two groups were moderate and similar to those reported in trials of rivastigmine for Alzheimer's disease. Rivastigmine-treated patients had a mean improvement of 2.1 points in the score for the 70-point ADAS-cog, from a baseline score of 23.8, as compared with a 0.7-point worsening in the placebo group, from a baseline score of 24.3 (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/7612/1/7612.pdf; https://discovery.ucl.ac.uk/id/eprint/7612/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/7612/1/7612.pdf; https://discovery.ucl.ac.uk/id/eprint/7612/ |
| Rights: |
open |
| Accession Number: |
edsbas.3E23341C |
| Database: |
BASE |