| Title: |
Brain activation by disgust-inducing pictures in obsessive-compulsive disorder |
| Authors: |
Nathan A. Shapira; Yijun Liu; Alex G. He; Margaret M. Bradley; Mary C. Lessig; George A. James; Dan J. Stein; Peter J. Lang; Wayne K. Goodman |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
http://fmri.mbi.ufl.edu/articles/2003Shapira-disgust OCD.pdf. |
| Publication Year: |
2003 |
| Collection: |
CiteSeerX |
| Subject Terms: |
Key Words; Disgust; obsessive-compulsive disorder |
| Description: |
Background: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disor-der (OCD). Methods: Eight OCD subjects with contamination preoc-cupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans. Results: A different distribution of brain activations was found during disgust-inducing visual stimulation in sev-eral areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-induc-ing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites. Conclusions: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non–contam-ination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed. Biol Psychiatry |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.452.1033 |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.452.1033; http://fmri.mbi.ufl.edu/articles/2003Shapira-disgust OCD.pdf |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.3E660DAC |
| Database: |
BASE |