Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.
| Title: | Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. |
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| Authors: | Medici M; Porcu E; Pistis G; Teumer A; Brown Sj; Jensen Ra; Rawal R; Roef Gl; Plantinga Ts; Vermeulen Sh; Lahti J; Simmonds Mj; Husemoen Ll; Freathy Rm; Shields Bm; Pietzner D; Nagy R; Broer L; Chaker L; Korevaar Ti; Plia Mg; Sala C; Völker U; Richards Jb; Sweep Fc; Gieger C; Corre T; Kajantie E; Thuesen B; Taes Ye; Visser We; Hattersley At; Kratzsch J; Hamilton A; Li W; Homuth G; Lobina M; Soranzo N; Cocca M; Nauck M; Spielhagen C; Ross A; Arnold A; van de Bunt M; Liyanarachchi S; Heier M; Grabe Hj; Masciullo C; Galesloot Te; Lim Em; Reischl E; Leedman Pj; Lai S; Delitala A; Bremner Ap; Philips Di; Beilby Jp; Mulas A; Vocale M; Abecasis G; Forsen T; James A; Widen E; Hui J; Prokisch H; Rietzschel Ee; Palotie A; Feddema P; Fletcher Sj; Schramm K; Rotter Ji; Kluttig A; Radke D; Traglia M; Surdulescu Gl; He H; Franklyn Ja; Tiller D; Vaidya B; de Meyer T; Jørgensen T; Eriksson Jg; O'Leary Pc; Wichmann E; Hermus Ar; Psaty Bm; Ittermann T; Hofman A; Bosi E; Schlessinger D; Wallaschofski H; Pirastu N; Aulchenko Ys; de la Chapelle A; Netea Maier Rt; Gough Sc; Meyer Zu Schwabedissen H; Frayling Tm; Kaufman Jm; Linneberg A; Räikkönen K; Smit Jw; Kiemeney La; Rivadeneira F; Uitterlinden Ag; Walsh Jp; Meisinger C; den Heijer M; Visser Tj; Spector Td; Wilson Sg; Völzke H; Cappola A; Toniolo D; Sanna S; Naitza S; Peeters Rp; MARIOTTI, STEFANO |
| Contributors: | Medici, M; Porcu, E; Pistis, G; Teumer, A; Brown, Sj; Jensen, Ra; Rawal, R; Roef, Gl; Plantinga, T; Vermeulen, Sh; Lahti, J; Simmonds, Mj; Husemoen, Ll; Freathy, Rm; Shields, Bm; Pietzner, D; Nagy, R; Broer, L; Chaker, L; Korevaar, Ti; Plia, Mg; Sala, C; Völker, U; Richards, Jb; Sweep, Fc; Gieger, C; Corre, T; Kajantie, E; Thuesen, B; Taes, Ye; Visser, We; Hattersley, At; Kratzsch, J; Hamilton, A; Li, W; Homuth, G; Lobina, M; Mariotti, Stefano; Soranzo, N; Cocca, M; Nauck, M; Spielhagen, C; Ross, A; Arnold, A; van de Bunt, M; Liyanarachchi, S; Heier, M; Grabe, Hj; Masciullo, C; Galesloot, Te; Lim, Em; Reischl, E; Leedman, Pj; Lai, S; Delitala, A; Bremner, Ap; Philips, Di; Beilby, Jp; Mulas, A; Vocale, M; Abecasis, G; Forsen, T; James, A; Widen, E; Hui, J; Prokisch, H; Rietzschel, Ee; Palotie, A; Feddema, P; Fletcher, Sj; Schramm, K; Rotter, Ji; Kluttig, A; Radke, D; Traglia, M; Surdulescu, Gl; He, H; Franklyn, Ja; Tiller, D; Vaidya, B; de Meyer, T; Jørgensen, T; Eriksson, Jg; O'Leary, Pc; Wichmann, E; Hermus, Ar; Psaty, Bm; Ittermann, T; Hofman, A; Bosi, E; Schlessinger, D; Wallaschofski, H; Pirastu, N; Aulchenko, Y; de la Chapelle, A; Netea Maier, Rt; Gough, Sc; Meyer Zu Schwabedissen, H; Frayling, Tm; Kaufman, Jm |
| Publication Year: | 2014 |
| Collection: | Università degli Studi di Cagliari: UNICA IRIS |
| Subject Terms: | thyroid peroxidase antibody; thyrotropin; autoantibody; iodide peroxidase; thyroid microsomal antibodie; adult; aged; antibody blood level; article; ATXN2 gene; autoimmune disease; autoimmune thyroid disease; autoimmunity; Bach2 gene; cancer risk; controlled study; female; gene; gene frequency; gene identification; gene locu; genetic association; genetic variability; goiter; Graves disease; Hashimoto disease; human; kalrn gene; MAGI3 gene; major clinical study |
| Description: | Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely unknown, we performed GWAS meta-analyses in 18,297 individuals for TPOAb-positivity (1769 TPOAb-positives and 16,528 TPOAb-negatives) and in 12,353 individuals for TPOAb serum levels, with replication in 8,990 individuals. Significant associations (P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24586183; info:eu-repo/semantics/altIdentifier/wos/WOS:000332021500001; volume:10; issue:2; firstpage:e1004123-1; lastpage:e1004123-13; numberofpages:13; journal:PLOS GENETICS; https://hdl.handle.net/11584/108236 |
| DOI: | 10.1371/journal.pgen.1004123 |
| Availability: | https://hdl.handle.net/11584/108236; https://doi.org/10.1371/journal.pgen.1004123 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.3E92674 |
| Database: | BASE |