Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group
| Title: | Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group |
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| Authors: | Colbert, Sarah M. C.; Monson, Eric T.; Andreassen, Ole A.; Ayinde, Olatunde O.; Barr, Peter B.; Bejan, Cosmin A.; Ceja, Zuriel; Coon, Hilary; DiBlasi, Emily; Edenberg, Howard J.; Gelernter, Joel; Hatoum, Alexander; Izotova, Anastasia; Johnson, Emma C.; Kaufman, Erin A.; Kranzler, Henry R.; Koromina, Maria; Lehto, Kelli; Myung, Woojae; Nurnberger, John I.; Serretti, Alessandro; Smoller, Jordan W.; Stein, Murray B.; Zai, Clement C.; Erlangsen, Annette; Gaine, Marie; Martorell, Lourdes; Sud, Reeteka; Toma, Claudio; Bigdeli, Tim B.; Kimbrel, Nathan A.; Ruderfer, Douglas; Docherty, Anna R.; Mann, J. John; Mullins, Niamh; undefined, undefined; Colbert, Sarah MC; Ayinde, Olatunde; Hatoum, Alexander S.; Ruderfer, Douglas M.; Adams, Mark; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Air, Tracy M.; Alda, Martin; Alfredsson, Lars; Anjorin, Adebayo; Appadurai, Vivek; Artigas, María Soler; Ashley-Koch, Allison E.; Awasthi, Swapnil; Azevedo, M. Helena; García, Enrique Baca; Bakian, Amanda; Bass, Nicholas; Bau, Claiton HD; Baune, Bernhard T.; Beckham, Jean C.; Bellivier, Frank; Bergen, Andrew W.; Berger, Klaus; Berrettini, Wade H.; Biernacka, Joanna M.; Binder, Elisabeth B.; Boehnke, Michael; Bohus, Martin; Boks, Marco P.; Børglum, Anders D.; Bosch, Rosa; Braff, David L.; Brandt, Harry; Breen, Gerome; Bryant, Richard; Budde, Monika; Bulik, Cynthia M.; Byrne, Enda M.; Cahn, Wiepke; Campos, Adrian I.; Casas, Miguel; Castelao, Enrique; Cervilla, Jorge A.; Chang, Xiao; Chaumette, Boris; Chen, Hsi-Chung; Chen, Wei J.; Christensen, Erik D.; Cichon, Sven; Coleman, Jonathan R. I.; Corvin, Aiden; Craddock, Nicholas; Craig, David; Crawford, Steven; Crow, Scott; Degenhardt, Franziska; Demontis, Ditte; Dennis, Michelle; Djurovic, Srdjan; Duriez, Philibert; Edwards, Alexis; Esko, Tõnu; Fanelli, Giuseppe; Fanous, Ayman H.; Fernández-Aranda, Fernando; Fichter, Manfred M.; Foo, Jerome C.; Forstner, Andreas J.; Fries, Gabriel R.; Frye, Mark; Fullerton, Janice M.; Galfalvy, Hanga; Gallinger, Steven; Gandal, Michael; Garrett, Melanie; Gatt, Justine M.; Gejman, Pablo V.; Giegling, Ina; Glatt, Stephen J.; Gorwood, Philip; Grabe, Hans J.; Green, Melissa J.; Grevet, Eugenio H.; Grigoroiu-Serbanescu, Maria; Guo, Yiran; Gutierrez, Blanca; Gutierrez-Zotes, Alfonso; Guzman-Parra, Jose; Hafferty, Jonathan D.; Hair, Lauren; Hakonarson, Hakon; Halmi, Katherine A.; Hamilton, Steven P.; Hamshere, Marian L.; Hartmann, Annette M.; Harvey, Philip; Hauser, Elizabeth R.; Hauser, Michael A.; Hauser, Joanna; Heilmann-Heimbach, Stefanie; Hishimoto, Akitoyo; Hoffmann, Per; Hougaard, David M.; Huffman, Jennifer; Hwu, Hai-Gwo; Ising, Marcus; Jacobson, Daniel; Jain, Sonia; Jamain, Stéphane; Ji, Min; Jiménez-Murcia, Susana; Johnson, Craig; Jones, Ian; Jones, Lisa A.; Jonsson, Lina; Kahn, René S.; Kang, JooEun; Kaplan, Allan S.; Kaye, Walter H.; Keel, Pamela K.; Kelsoe, John R.; Kendler, Kenneth S.; Kennedy, James L.; Kessler, Ronald C.; Kim, Minsoo; Kloiber, Stefan; Klump, Kelly L.; Koenen, Karestan C.; Kogevinas, Manolis; Konte, Bettina; Krebs, Marie-Odile; Kuo, Po-Hsiu; Landén, Mikael; Lannoy, Séverine; Lawrence, Jacob; Leboyer, Marion; Lee, Phil H.; Levey, Daniel F.; Levinson, Douglas F.; Lewis, Cathryn M.; Li, Dong; Li, Qingqin S.; Liao, Shih-Cheng; Liao, Calwing; Lieb, Klaus; Lilenfeld, Lisa; Lindquist, Jennifer H.; Lissowska, Jolanta; Liu, Chih-Min; Lori, Adriana; Lucae, Susanne; Madduri, Ravi; Magistretti, Pierre J.; Marshall, Christian R.; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McGrath, Patrick; McGuffin, Peter; McIntosh, Andrew M.; McMahon, Benjamin; McQuillin, Andrew; Medland, Sarah E.; Mehta, Divya; Melle, Ingrid; Milaneschi, Yuri; Mitchell, James E.; Mitchell, Philip B.; Molina, Esther; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Muntané, Gerard; Murnyak, Balasz; Myers, Richard M.; Nievergelt, Caroline; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O’Donovan, Michael C.; Okazaki, Satoshi; Olsen, Catherine M.; Ophoff, Roel A.; Oslin, David W.; Otsuka, Ikuo; Owen, Michael J.; Papiol, Sergi; Pato, Carlos; Pato, Michele T.; Penninx, Brenda WJH; Pimm, Jonathan; Pinto, Dalila; Pistis, Giorgio; Polimanti, Renato; Porteous, David; Potash, James B.; Power, Robert A.; Powers, Abigail; Preisig, Martin; Qin, Xuejun; Quested, Digby; Ramos-Quiroga, Josep Antoni; Ramoz, Nicolas; Reif, Andreas; Rentería, Miguel E.; Ribasés, Marta; Richarte, Vanesa; Rietschel, Marcella; Ripke, Stephan; Rivera, Margarita; Roberts, Andrea; Roberts, Gloria; Roepke, Stefan; Rouleau, Guy A.; Rovaris, Diego L.; Rozanov, Vsevolod; Rujescu, Dan; Sànchez-Gistau, Vanessa; Sánchez-Mora, Cristina; Sanders, Alan R.; Sawyers, Chelsea; Scherer, Stephen W.; Schmahl, Christian; Schofield, Peter R.; Schulze, Thomas G.; Scott, Laura J.; Shabalin, Andrey; Shi, Jianxin; Shyn, Stanley I.; Sirignano, Lea; Sklar, Pamela; Smeland, Olav B.; Smith, Daniel J.; Sokolowski, Marcus; Sonuga-Barke, Edmund J. S.; Spalletta, Gianfranco; Stahl, Eli A.; Starnawska, Anna; Stephenson, Mallory; Strauss, John S.; Streit, Fabian; Strober, Michael; Su, Mei-Hsin; Świątkowska, Beata; Thornton, Laura M.; Trafton, Jodie; Treasure, Janet; Trzaskowski, Maciej; Tsuang, Ming T.; Turecki, Gustavo; Ursano, Robert J.; Van der Auwera, Sandra; Vilar-Ribó, Laura; Vilella, Elisabet; Vincent, John B.; Völzke, Henry; Walss-Bass, Consuelo; Walters, James TR; Ware, Erin B.; Wasserman, Danuta; Watson, Hunna J.; Weickert, Cynthia Shannon; Weickert, Thomas W.; Weissman, Myrna M.; Wendt, Frank; Werge, Thomas; Whiteman, David C.; Williams, Leanne M.; Willour, Virginia; Witt, Stephanie H.; Woodside, D. Blake; Wray, Naomi R.; Yilmaz, Zeynep; Zillich, Lea |
| Publisher Information: | Springer Nature [academic journals on nature.com] |
| Publication Year: | 2025 |
| Collection: | Cardiff University: ORCA (Online Research @ Cardiff) |
| Description: | Suicidality phenotypes, consisting of suicidal ideation (SI), suicide attempt (SA), and suicide death (SD), are all heritable but present unique challenges in genome-wide association studies (GWAS) due to their individual complexity, overlap with each other and with related self-harm phenotypes, and varying associations with psychiatric disorders. GWAS have uncovered several loci associated with suicidality phenotypes by meta-analyzing data from multiple cohorts. However, combining datasets from many research groups, where each group may use different study designs, phenotyping instruments, and definitions of suicidality phenotypes, presents challenges. Heterogeneity resulting from these differences can limit genetic discovery; harmonizing phenotype definitions to ensure consistency will greatly improve results. Here, we describe a standardized phenotyping protocol that draws on the expertise of a subgroup of clinicians, researchers, and experts from the Psychiatric Genomics Consortium Suicide Working Group to propose consensus definitions for SI, SA, and SD for genetic studies. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://orca.cardiff.ac.uk/id/eprint/183876/1/s41380-025-03271-y.pdf; Colbert, Sarah M. C., Monson, Eric T., Andreassen, Ole A., Ayinde, Olatunde O., Barr, Peter B., Bejan, Cosmin A., Ceja, Zuriel, Coon, Hilary, DiBlasi, Emily, Edenberg, Howard J., Gelernter, Joel, Hatoum, Alexander, Izotova, Anastasia, Johnson, Emma C., Kaufman, Erin A., Kranzler, Henry R., Koromina, Maria, Lehto, Kelli, Myung, Woojae, Nurnberger, John I., Serretti, Alessandro, Smoller, Jordan W., Stein, Murray B., Zai, Clement C., Erlangsen, Annette, Gaine, Marie, Martorell, Lourdes, Sud, Reeteka, Toma, Claudio, Bigdeli, Tim B., Kimbrel, Nathan A., Ruderfer, Douglas, Docherty, Anna R., Mann, J. John, Mullins, Niamh, undefined, undefined, Colbert, Sarah MC, Ayinde, Olatunde, Hatoum, Alexander S., Ruderfer, Douglas M., Adams, Mark, Adolfsson, Rolf, Agartz, Ingrid, Agerbo, Esben, Air, Tracy M., Alda, Martin, Alfredsson, Lars, Anjorin, Adebayo, Appadurai, Vivek, Artigas, María Soler, Ashley-Koch, Allison E., Awasthi, Swapnil, Azevedo, M. Helena, García, Enrique Baca, Bakian, Amanda, Bass, Nicholas, Bau, Claiton HD, Baune, Bernhard T., Beckham, Jean C., Bellivier, Frank, Bergen, Andrew W., Berger, Klaus, Berrettini, Wade H., Biernacka, Joanna M., Bigdeli, Tim B., Binder, Elisabeth B., Boehnke, Michael, Bohus, Martin, Boks, Marco P., Børglum, Anders D., Bosch, Rosa, Braff, David L., Brandt, Harry, Breen, Gerome, Bryant, Richard, Budde, Monika, Bulik, Cynthia M., Byrne, Enda M., Cahn, Wiepke, Campos, Adrian I., Casas, Miguel, Castelao, Enrique, Cervilla, Jorge A., Chang, Xiao, Chaumette, Boris, Chen, Hsi-Chung, Chen, Wei J., Christensen, Erik D., Cichon, Sven, Coleman, Jonathan R. I., Corvin, Aiden, Craddock, Nicholas https://orca.cardiff.ac.uk/view/cardiffauthors/A069870V.html orcid:0000-0003-2171-0610 orcid:0000-0003-2171-0610, Craig, David, Crawford, Steven, Crow, Scott, Degenhardt, Franziska, Demontis, Ditte, Dennis, Michelle, Djurovic, Srdjan, Duriez, Philibert, Edwards, Alexis, Esko, Tõnu, Fanelli, Giuseppe, Fanous, Ayman H., Fernández-Aranda, Fernando, Fichter, Manfred M., Foo, Jerome C., Forstner, Andreas J., Fries, Gabriel R., Frye, Mark, Fullerton, Janice M., Galfalvy, Hanga, Gallinger, Steven, Gandal, Michael, Garrett, Melanie, Gatt, Justine M., Gejman, Pablo V., Giegling, Ina, Glatt, Stephen J., Gorwood, Philip, Grabe, Hans J., Green, Melissa J., Grevet, Eugenio H., Grigoroiu-Serbanescu, Maria, Guo, Yiran, Gutierrez, Blanca, Gutierrez-Zotes, Alfonso, Guzman-Parra, Jose, Hafferty, Jonathan D., Hair, Lauren, Hakonarson, Hakon, Halmi, Katherine A., Hamilton, Steven P., Hamshere, Marian L. https://orca.cardiff.ac.uk/view/cardiffauthors/A0234260.html orcid:0000-0002-8990-0958 orcid:0000-0002-8990-0958, Hartmann, Annette M., Harvey, Philip, Hauser, Elizabeth R., Hauser, Michael A., Hauser, Joanna, Heilmann-Heimbach, Stefanie, Hishimoto, Akitoyo, Hoffmann, Per, Hougaard, David M., Huffman, Jennifer, Hwu, Hai-Gwo, Ising, Marcus, Jacobson, Daniel, Jain, Sonia, Jamain, Stéphane, Ji, Min, Jiménez-Murcia, Susana, Johnson, Craig, Jones, Ian https://orca.cardiff.ac.uk/view/cardiffauthors/A069946N.html orcid:0000-0001-5821-5889 orcid:0000-0001-5821-5889, Jones, Lisa A., Jonsson, Lina, Kahn, René S., Kang, JooEun, Kaplan, Allan S., Kaye, Walter H., Keel, Pamela K., Kelsoe, John R., Kendler, Kenneth S., Kennedy, James L., Kessler, Ronald C., Kim, Minsoo, Kloiber, Stefan, Klump, Kelly L., Koenen, Karestan C., Kogevinas, Manolis, Konte, Bettina, Krebs, Marie-Odile, Kuo, Po-Hsiu, Landén, Mikael, Lannoy, Séverine, Lawrence, Jacob, Leboyer, Marion, Lee, Phil H., Levey, Daniel F., Levinson, Douglas F., Lewis, Cathryn M., Li, Dong, Li, Qingqin S., Liao, Shih-Cheng, Liao, Calwing, Lieb, Klaus, Lilenfeld, Lisa, Lindquist, Jennifer H., Lissowska, Jolanta, Liu, Chih-Min, Lori, Adriana, Lucae, Susanne, Madduri, Ravi, Magistretti, Pierre J., Marshall, Christian R., Martin, Nicholas G., Mayoral, Fermin, McElroy, Susan L., McGrath, Patrick, McGuffin, Peter, McIntosh, Andrew M., McMahon, Benjamin, McQuillin, Andrew, Medland, Sarah E., Mehta, Divya, Melle, Ingrid, Milaneschi, Yuri, Mitchell, James E., Mitchell, Philip B., Molina, Esther, Morken, Gunnar, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Muntané, Gerard, Murnyak, Balasz, Myers, Richard M., Nievergelt, Caroline, Nimgaonkar, Vishwajit, Nordentoft, Merete, Nöthen, Markus M., O’Donovan, Michael C. https://orca.cardiff.ac.uk/view/cardiffauthors/A038895E.html orcid:0000-0001-7073-2379 orcid:0000-0001-7073-2379, Okazaki, Satoshi, Olsen, Catherine M., Ophoff, Roel A., Oslin, David W., Otsuka, Ikuo, Owen, Michael J. https://orca.cardiff.ac.uk/view/cardiffauthors/A069868J.html orcid:0000-0003-4798-0862 orcid:0000-0003-4798-0862, Papiol, Sergi, Pato, Carlos, Pato, Michele T., Penninx, Brenda WJH, Pimm, Jonathan, Pinto, Dalila, Pistis, Giorgio, Polimanti, Renato, Porteous, David, Potash, James B., Power, Robert A., Powers, Abigail, Preisig, Martin, Qin, Xuejun, Quested, Digby, Ramos-Quiroga, Josep Antoni, Ramoz, Nicolas, Reif, Andreas, Rentería, Miguel E., Ribasés, Marta, Richarte, Vanesa, Rietschel, Marcella, Ripke, Stephan, Rivera, Margarita, Roberts, Andrea, Roberts, Gloria, Roepke, Stefan, Rouleau, Guy A., Rovaris, Diego L., Rozanov, Vsevolod, Rujescu, Dan, Sànchez-Gistau, Vanessa, Sánchez-Mora, Cristina, Sanders, Alan R., Sawyers, Chelsea, Scherer, Stephen W., Schmahl, Christian, Schofield, Peter R., Schulze, Thomas G., Scott, Laura J., Shabalin, Andrey, Shi, Jianxin, Shyn, Stanley I., Sirignano, Lea, Sklar, Pamela, Smeland, Olav B., Smith, Daniel J., Sokolowski, Marcus, Sonuga-Barke, Edmund J. S., Spalletta, Gianfranco, Stahl, Eli A., Starnawska, Anna, Stephenson, Mallory, Strauss, John S., Streit, Fabian, Strober, Michael, Su, Mei-Hsin, Świątkowska, Beata, Thornton, Laura M., Trafton, Jodie, Treasure, Janet, Trzaskowski, Maciej, Tsuang, Ming T., Turecki, Gustavo, Ursano, Robert J., Van der Auwera, Sandra, Vilar-Ribó, Laura, Vilella, Elisabet, Vincent, John B., Völzke, Henry, Walss-Bass, Consuelo, Walters, James TR https://orca.cardiff.ac.uk/view/cardiffauthors/A0230062.html orcid:0000-0002-6980-4053 orcid:0000-0002-6980-4053, Ware, Erin B., Wasserman, Danuta, Watson, Hunna J., Weickert, Cynthia Shannon, Weickert, Thomas W., Weissman, Myrna M., Wendt, Frank, Werge, Thomas, Whiteman, David C., Williams, Leanne M., Willour, Virginia, Witt, Stephanie H., Woodside, D. Blake, Wray, Naomi R., Yilmaz, Zeynep and Zillich, Lea 2025. Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group. Molecular Psychiatry 30 , pp. 6144-6154. 10.1038/s41380-025-03271-y https://doi.org/10.1038/s41380-025-03271-y file https://orca.cardiff.ac.uk/id/eprint/183876/1/s41380-025-03271-y.pdf |
| DOI: | 10.1038/s41380-025-03271-y |
| Availability: | https://orca.cardiff.ac.uk/id/eprint/183876/; https://doi.org/10.1038/s41380-025-03271-y |
| Rights: | cc_by_nc_nd_4_0 |
| Accession Number: | edsbas.3E98484F |
| Database: | BASE |