| Title: |
High frequency of Specific Polysaccharide Antibody Deficiency (SPAD) in adults with unexplained, recurrent and/or severe infections with encapsulated bacteria. |
| Authors: |
Stabler, Sarah; Lamblin, Catherine; Gaillard, Sacha; Juste, Nicolas; Mihailescu, Mirela; Viget, Nathalie; Sy Ndiaye, Thierno; Dzeing Ella, Arnaud; Weyrich, Pierre; Prevotat, Anne; Chenivesse, Cecile; Le Rouzic, Olivier; Mortuaire, Geoffrey; Vuotto, Fanny; Faure, Karine; Leurs, Amelie; Wallet, Frederic; Loiez, Caroline; Titecat, Marie; Le Guern, Rémi; Hachulla, Eric; Sanges, Sebastien; Etienne, Nicolas; Launay, David; Lopez, Benjamin; Bahuaud, Mathilde; Batteux, Frédéric; Dubucquoi, Sylvain; Gesquière-Lasselin, Cyrielle; Labalette, Myriam; Lefevre, Guillaume |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 CIIL; Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France CeRAINO; Ramsay Générale de Santé - Hôpital Privé La Louvière; Groupe Hospitalier de l'Institut Catholique de Lille GHICL; Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017; Institute for Translational Research in Inflammation - U 1286 INFINITE (Ex-Liric); Institut de Microbiologie CHRU Lille; Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286; Institut d'Immunologie CHRU Lille; Institut Cochin IC UM3 (UMR 8104 / U1016) |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Streptococcus pneumoniae; vaccine response; primary immunodeficiency; specific anti-polysaccharide deficiency (SPAD) |
| Description: |
Background Primary immunodeficiencies (PIDs) in adults are mainly revealed by recurrent and/or severe bacterial infections. The objective of this study was to evaluate a systematic research strategy of PIDs in adults with unexplained bacterial infections, with a special focus on specific polysaccharide antibody deficiency (SPAD). Methods In this prospective multicenter study, inclusion criteria were recurrent benign upper and lower respiratory tract infections (RTIs) for at least two years (group 1), at least one upper or lower RTI requiring hospitalization (group 2), and/or at least one invasive infection documented with encapsulated bacteria (group 3). Main exclusion criteria were all local and general conditions that could explain infections. If no PID diagnosis was made, response to polysaccharide antigens was assessed using a pneumococcal polysaccharide vaccine. Results From March 2015 to March 2020, 118 patients were included (37 males, median age of 41 years): 73, 17, and 28 in groups 1, 2, and 3, respectively. Forty-seven PIDs were diagnosed, giving an estimated frequency of 39.8% (95% confidence interval [CI] [30.4, 48.8]). SPAD was the most frequent diagnosis by far (n = 37/47, 78.7%), and was made in 23, 5, and 9 patients from groups 1 to 3, respectively. All SPAD patients received conjugate vaccines and, according to their infectious history, were on surveillance or treated with preventive antibiotics (n = 6) and/or with immunoglobulins replacement therapy (n = 10), the latter being dramatically efficient in all cases. Conclusions Considering its high prevalence among adults with unexplained recurrent and/or severe bacterial infections, SPAD should be screened in those patients. Clinical Trials Registration NCT02972281. ; 76;800–808 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| Relation: |
Clinical Infectious Diseases; Clin Infect Dis; http://hdl.handle.net/20.500.12210/100707 |
| Availability: |
https://hdl.handle.net/20.500.12210/100707 |
| Accession Number: |
edsbas.3F7FA941 |
| Database: |
BASE |