| Title: |
T-CELL-MEDIATED CYTOTOXIC IMMUNE RESPONSES TO F9 TERATOCARCINOMA CELLS |
| Authors: |
Cytolytic Effector; T Cells Lyse; H--negative F; Cells; Syngeneic Spermatogonia; Hermann Wagner; Anna Starzinski-powitz; Martin Rollinghoff; Pierre Golstein; Hedwig Jakob |
| Contributors: |
The Pennsylvania State University CiteSeerX Archives |
| Source: |
ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b3/9c/J_Exp_Med_1978_Jan_1_147(1)_251-264.tar.gz |
| Collection: |
CiteSeerX |
| Description: |
Most if not all immune functions mediated by thymus-derived (T) lymphocytes appear to be associated with cell surface structures coded for by the major murine histocompatibility complex (MHC). 1 For example the central I-region of the MHC is critical for Ly 1-positive T helper cells (1-3), T cells transferring DTH reactions (4) and antibacterial immunity (5), and T cells proliferating in the MLC (6). In contrast Ly 2.3-positive cytotoxic T lymphocytes (CTL) specific for alloantigens (6-9), virus antigens (10-11), cell associated non-MHC-histocompatibility antigens (12-14), and haptens (15, 16) are functionally associated with the peripheral H-2K or H-2D region of the MHC. In the case of CTL it has been argued that their lytic function can take place only towards H-2positive targets. This argument is derived from results showing that both hapten and virus-specific H-2 restricted CTL are unable to lyse virus infected or hapten conjugated H-2-negative targets (17-18). If T cells must recognize H-2 gene products in addition to foreign antigens on cell surfaces to become sensitized or to mediate lytic effector functions, it should not be possible to induce CTL with specificity for H-2-negative target cells. In the experiments reported here this question has been tested using the H-2-negative embryonal carcinoma cell line F9 (19) as stimulator cells. |
| Document Type: |
text |
| File Description: |
application/zip |
| Language: |
English |
| Relation: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.2428 |
| Availability: |
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.273.2428 |
| Rights: |
Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: |
edsbas.3FBF295C |
| Database: |
BASE |