Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts
| Title: | Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts |
|---|---|
| Authors: | Gencer B; Collet TH; Virgini V; Bauer DC; Gussekloo J; Cappola AR; Nanchen D; den Elzen WP; Balmer P; Luben RN; Iacoviello M; Triggiani V; Cornuz J; Newman AB; Khaw KT; Jukema JW; Westendorp RG; Vittinghoff E; Aujesky D; Rodondi N; Thyroid Studies Collaboration. |
| Contributors: | Gencer, B; Collet, Th; Virgini, V; Bauer, Dc; Gussekloo, J; Cappola, Ar; Nanchen, D; den Elzen, Wp; Balmer, P; Luben, Rn; Iacoviello, M; Triggiani, V; Cornuz, J; Newman, Ab; Khaw, Kt; Jukema, Jw; Westendorp, Rg; Vittinghoff, E; Aujesky, D; Rodondi, N; Thyroid Studies, Collaboration. |
| Publication Year: | 2012 |
| Collection: | Università degli Studi di Foggia: CINECA IRIS Institutional Research Information System |
| Description: | BACKGROUND: American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events. METHODS AND RESULTS: We performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | Italian |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/22821943; info:eu-repo/semantics/altIdentifier/wos/WOS:000308355100014; volume:126; issue:9; firstpage:1040; lastpage:1049; numberofpages:10; journal:CIRCULATION; https://hdl.handle.net/11369/390135 |
| Availability: | https://hdl.handle.net/11369/390135 |
| Accession Number: | edsbas.3FE887F5 |
| Database: | BASE |