| Title: |
Opioid substitution therapy or hidden opioids are a minefield for nalmefene: an atypical case series of 11 patients in Lorraine |
| Authors: |
Yelehe-Okouma, Melissa; Martini, Hervé; Lemarié, Jérémie; Labroca, Pierre; Petitpain, Nadine; Gibaja, Valérie; Paille, François; Gillet, Pierre |
| Contributors: |
Service de Pharmacologie Clinique et Toxicologie CHRU Nancy; Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy); Service de Réanimation Médicale CHRU Nancy; Service de Réanimation Médicale, Hôpital de Mercy CHR Metz-Thionville; Centre hospitalier régional de Metz-Thionville (CHR Metz-Thionville); Csapa - Maison des Addictions Chru Nancy Central (MdA); Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA); Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS) |
| Source: |
ISSN: 0767-3981. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2017 |
| Collection: |
Université de Lorraine: HAL |
| Subject Terms: |
opioid withdrawal syndrome; nalmefene; opioid substitution therapy; [SDV]Life Sciences [q-bio]; [SDV.TOX]Life Sciences [q-bio]/Toxicology |
| Description: |
International audience ; Opioid antagonists such as naltrexone and nalmefene are used in drug therapy for alcoholism. Nalmefene, approved in Europe in February 2013 for the reduction of alcohol consumption, is used in patients with alcohol dependence. We report 11 cases of opioid withdrawal syndrome after a single dose of nalmefene in patients usually treated with methadone, buprenorphine, but also with fentanyl or loperamide. Nalmefene is both a partial agonist and an antagonist of opioid receptors. Regarding to its opioid antagonist activity, nalmefene is contraindicated in patients with an opioid treatment. Therefore, when prescribing or delivering nalmefene, healthcare professionals need to be vigilant about any type of opioid exposure, even masked or hidden, to avoid these potential life-threatening syndromes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28322465; PUBMED: 28322465 |
| DOI: |
10.1111/fcp.12286 |
| Availability: |
https://hal.science/hal-01713582; https://doi.org/10.1111/fcp.12286 |
| Accession Number: |
edsbas.40129A76 |
| Database: |
BASE |