| Title: |
High Efficacy of β-Blockers in Long-QT Syndrome Type 1 ; Contribution of Noncompliance and QT-Prolonging Drugs to the Occurrence of β-Blocker Treatment “Failures” |
| Authors: |
Vincent, G. Michael; Schwartz, Peter J.; Denjoy, Isabelle; Swan, Heikki; Bithell, Candice; Spazzolini, Carla; Crotti, Lia; Piippo, Kirsi; Lupoglazoff, Jean-Marc; Villain, Elizabeth; Priori, Silvia G.; Napolitano, Carlo; Zhang, Li |
| Source: |
Circulation ; volume 119, issue 2, page 215-221 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2009 |
| Description: |
Background— β-Blocker efficacy in long-QT syndrome type 1 is good but variably reported, and the causes of cardiac events despite β-blocker therapy have not been ascertained. Methods and Results— This was a retrospective study of the details surrounding cardiac events in 216 genotyped long-QT syndrome type 1 patients treated with β-blocker and followed up for a median time of 10 years. Before β-blocker, cardiac events occurred in 157 patients (73%) at a median age of 9 years, with cardiac arrest (CA) in 26 (12%). QT-prolonging drugs were used by 17 patients; 9 of 17 (53%) had CA compared with 17 of 199 nonusers (8.5%; odds ratio, 12.0; 95% confidence interval, 4.1 to 35.3; P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circulationaha.108.772533 |
| DOI: |
10.1161/CIRCULATIONAHA.108.772533 |
| Availability: |
https://doi.org/10.1161/circulationaha.108.772533; https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.108.772533 |
| Accession Number: |
edsbas.40285899 |
| Database: |
BASE |