Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury.
| Title: | Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. |
|---|---|
| Authors: | Iain Stewart; Joseph Jacob; Joanna C Porter; Bin Liu; Amanda L Tatler; Nancy Gomez; Matthew R Pugh; Alison E John; Richard J Allen; John F Blaikley; Nazia Chaudhuri; Emma Denneny; Laura Fabbri; Peter M George; Beatriz Guillen-Guio; Bibek Gooptu; Ian P Hall; Ling Pei Ho; Ian Jarrold; Simon Johnson; Mark G Jones; Fasihul Khan; Puja Mehta; Jane Mitchell; Philip L Molyneaux; John Pearl; Karen Piper Hanley; Manuela Platé; Valerie Quinn; Pilar Rivera-Ortega; Laura C Saunders; David JF Smith; Mark Spears; Lisa G Spencer; Stefan C Stanel; AA Roger Thompson; Simon Walsh; Jim M Wild; Dan G Wootton; Annemarie B Docherty; Fergus Gleeson; William Greenhalf; Ewen M Harrison; Nazir Lone; Jennifer Quint; Anastasia Maslova; Moritz Pohl; Adam Stephens; Simon Young; Amisha Singapuri; Aarti Shikotra; Marco Sereno; Ruth Saunders; Matthew Richardson; Betty Raman; Krisnah Poinasamy; Hamish McAuley; Michael Marks; Olivia C Leavy; Linzy Houchen-Wolloff; Alex Horsley; Victoria C Harris; Neil Greening; Rachael Evans; Omer Elneima; James D Chalmers; Christopher Brightling; Rachel C Chambers; Louise Wain; R Gisli Jenkins; PHOSP-COVID Collaborative Group and the UKILD Consortium |
| Publication Year: | 2026 |
| Collection: | University of Leicester: Figshare |
| Subject Terms: | Clinical sciences; Health sciences; Epidemiology; Biomarker; COVID-19; Epithelial; Hospitalisation; Lung injury |
| Description: | BACKGROUND: Long term respiratory symptoms are reported following recovery of acute COVID-19 infection and residual lung abnormalities (RLA) on follow-up thoracic computed tomography (CT) after COVID-19 hospitalisation have been observed. It is unknown whether RLA are associated with epithelial lung injury. METHODS: Plasma was sampled from the observational Post HOSPitalisation-COVID cohort at five months post-hospitalisation. Epithelial injury biomarkers Krebs von den Lungen-6 (KL-6), matrix metalloproteinase 7 (MMP-7), surfactant protein-D (SP-D) and surfactant protein-A (SP-A) were assayed. In those without follow-up CT, RLA at-risk was defined by percent predicted DLCO |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | 2381/31325383.v1 |
| Availability: | https://figshare.com/articles/journal_contribution/Residual_lung_abnormality_following_COVID-19_hospitalisation_is_characterised_by_biomarkers_of_epithelial_injury_/31325383 |
| Rights: | CC BY 4.0 |
| Accession Number: | edsbas.402CFC4E |
| Database: | BASE |