| Title: |
Increased incidence of diabetes in people living with HIV treated with first‐line integrase strand transfer inhibitors: A French multicentre retrospective study |
| Authors: |
Ursenbach, Axel; Sireyjol, Antoine; Delpierre, Cyrille; Duvivier, Claudine; Hocqueloux, Laurent; Rey, David; Chirouze, C; Bouiller, K; Bozon, F; S Brunel, A; Hustache-Mathieu, L; Lagoutte, J; Lepiller, Q; Marty-Quinternet, S; Pépin-Puget, L; Rosolen, B; Tissot, N; Jaffuel, S; Ansart, S; Quintric, Y; Rezig, S; Quaesaet, L; Gazeau, P; Jacomet, C; Mrozek, N; Theis, C; Vidal, M; Richaud, C; Anglade, F; Sauvat, L; Corbin, V; Aumeran, Claire; Baud, O; Goncalvez, E; Mazzocolin, D; Mirand, A; Brebion, A; Henquell, C; Lamaury, I; Breugnon, E; Chéret, A; Curlier, E; Duvallon, E; Fabre, I; Herrmann-Storck, C; Markowicz, S; Marquet, M; Ouissa, R; Pradat-Paz, L; Samar, K; Tressieres, B; Merrien, D; Bollangier, O; Boucher, D; Guimard, T; Laine, L; Leautez, S; Morrier, M; Perré, P; Point, P; Roncato-Saberan, M; Pouget-Abadie, X; Chapuzet, C; Faba, L; F Faucher, J; Cypierre, A; Ducroix-Roubertou, S; Durox, H; Genet-Villeger, C; Pascual, J; Pinet, P; Codde, C; Rogez, S; B Woillard, J; Benoist, C; Alfaiate, D; Becker, A; Cotte, L; Ader, F; Brochier, C; Brunel-Dalmas, F; Cannesson, O; Conrad, A; Degroodt, S; Ferry, T; Godinot, M; Icard, V; M Livrozet, J; Makhloufi, D; Perpoint, T; Roux, S; a Trabaud, M; Triffault-Fillit, C; Valour, F; S Batalla, A; Lardot, H; Simon, M; Javaux, C; Ravaux, I; Ménard, A; Belkhir, Y; Colson, P; Dhiver, C; Martin-Degioanni, M; Meddeb, L; Mokhtari, M; Motte, A; Tissot-Dupont, H; Toméi, C; Brégigeon, S; Zaegel-Faucher, O; Laroche, H; Dos Santos, M; J Ducassou, M; Galie, S; Ivanova, A; Jaquet, I; Obry-Roguet, V; Orticoni, M; Ressiot, E; S Ritleng, A; Benkouiten, S; Cabié, A; Abel, S; Bigeard, B; Bidelogne, C; Cabras, O; Carnino, L; Cuzin, L; Fagour, L; Gros-Dubois, A; Guitteaud, K; Lahuna, C; Louis-Michel, E; Métais, A; Quenard, F; Pierre-François, S; Robert, C; Cavalli, Z; Bucy, L; Genet, R; Schneifer, C; Perez, P; Reynes, J; Bistoquet, M; Delaporte, E; Le Moing, V; Lejeune, J; Meftah, N; Merle de Boever, C; Montes, B; Montoya Ferrer, A; Pansu, N; Tuaillon, E; Lefèvre, B; André, M; Baronnet, G; Bevilacqua, S; Boyer, L; P Bouillon, M; Charmillon, A; Delestan, M; Emilie, C; Frentiu, E; Goehringer, F; Hénard, S; Jeanmaire, E; Rabaud, C; Radjabaly-Mandjee, A; Raffi, F; Allavena, C; André-Garnier, E; Asquier-Khati, A; Billaud, E; Biron, C; Bonnet, B; Bouchez, S; Boutoille, D; Brunet-Cartier, C; Cavellec, M; Deschanvres, C; J Gaborit, B; Grégoire, M; Jovelin, T; Lefebvre, M; Lecomte, R; Mahot, R; Morineau, P; Paredes, E; Reliquet, V; Soria, A; Bréaud, S; Buscot, M; Carles, M; Chirio, D; Cua, E; Dellamonica, P; Demonchy, E; de Monte, A; Durant, J; Ferrando, S; Naqvi, A; Perbost, I; Pradier, C; Prouvost-Keller, B; Risso, K; Touitou, I; Viot, A; Wehrlen-Pugliese, S; Pugliese, P; Sunder, S; Schepers, K; Goudet, V; dos Santos, A; Rzepecki, V; Hocqueloux, L; Béraud, G; Effa, J; Gubavu, C; Legros, V; Mille, C; Prazuck, T; Sève, A; Vitry d'Aubigny, L; Goujard, C; Castro-Gordon, A; David-Chevallier, P; Godard, V; Quertainmont, Y; Teicher, E; Jaureguiberry, S; Joly, V; Charpentier, C; Descamps, D; Digumber, M; Gervais, A; Ghosn, J; Julia, Z; Landman, R; Lariven, S; Le Gac, S; Louni, F; Peiffer-Smadja, N; Peytavin, G; Rioux, C; Yazdanpanah, Y; Duvivier, C; Amazzough, K; Benabdelmoumen, G; Bossi, P; Cessot, G; Charlier, C; H Consigny, P; de la Porte Des Vaux, C; Gomes-Pires, E; Hochedez, P; Jidar, K; Lafont, E; Lanternier, F; Lortholary, O; Louisin, C; Lourenco, J; Melenotte, C; Pacoud, O; Parize, P; Ruyno, F; Rouzaud, C; Serris, A; Taieb, F; Zeggagh, J; Palich, R; a Valantin, M; Katlama, C; Faycal, A; Agher, R; Dudoit, Y; Hamani, N; Qatib, N; Qzaibri, I; Lenclume, L; Schneider, L; Seang, S; Tubiana, R; Hall, N; Perfezou, P; C Duthe, J; B Drevillon, F; P Talarmin, J; Khatchatourian, L; Bani-Sadr, F; L Berger, J; Brodard, V; Hentzien, M; Kmiec, I; Lambert, D; Marty, H; N'Guyen, Y; Arvieux, C; Baldeyrou, M; Benezit, F; M Chapplain, J; Dupont, M; C Duthé, J; Ismaël, S; Lebot, A; Lemaitre, F; Luque-Paz, D; Maillard, A; Morlat, C; Patrat-Delon, S; Picard, L; Poisson-Vannier, M; Pronier M Revest, C; Tattevin, P; Vivent, J; Gagneux-Brunon, A; Botelho-Nevers, E; Frésard, A; Pouvaret, A; Ronat, V; Rey, D; Cheneau, C; Bernard-Henry, C; Fafi-Kremer, S; Fischer, P; Gantner, P; Mélounou, C; Ursenbach, A; Klee, P; Hansmann, Y; Lefebvre, N; Ruch, Y; Danion, F; Hoellinger, B; Lemmet, T; Gerber, V; Delobel, P; Alvarez, M; Biezunski, N; Boumaza, X; Debard, A; Delpierre, C; Garnier, C; Lelièvre, L; Martin-Blondel, G; Piffaut, M; Rastoll, C; Saune, K; Robineau, O; Aïssi, E; Alidjinou, E; Baclet, V; Bocket, L; Boucher, A; Derdour, V; Lafon-Desmurs, B; Meybeck, A; Pradier, M; Tetart, M; Valette, M; Viget, N; Diarra, A; Corvaisier, G; Brière, M; de la Chapelle, M; Gousseff, M; Le Goff, M; Thierry, M |
| Contributors: |
Le Trait d'Union, centre de soins de l'infection par le VIH CHU Strasbourg; Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg); Hôpitaux Universitaires de Strasbourg (HUS)-Hôpitaux Universitaires de Strasbourg (HUS); Statoscop; Equipe EQUITY (CERPOP); Centre d'Epidémiologie et de Recherche en santé des POPulations (CERPOP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse); Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Centre Hospitalier Regional d'Orléans (CHRO); Dat’AIDS Study Group; Service Maladies Infectieuses et Tropicales CHU Clermont-Ferrand; Pôle RHEUNNIRS CHU Clermont-Ferrand; CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand-CHU Gabriel Montpied Clermont-Ferrand; CHU Clermont-Ferrand-CHU Clermont-Ferrand; Laboratoire Microorganismes : Génome et Environnement (LMGE); Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA); Service Hygiène Hospitalière CHU Clermont-Ferrand; Université Clermont Auvergne (UCA) |
| Source: |
ISSN: 1464-2662. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2025 |
| Collection: |
Université Toulouse III - Paul Sabatier: HAL-UPS |
| Subject Terms: |
integrase strand transfer inhibitors; integrase inhibitors; diabetes; antiretroviral therapy; HIV; MESH: Adult; MESH: Diabetes Mellitus* / chemically induced; MESH: HIV Infections* / drug therapy; MESH: HIV Integrase Inhibitors* / adverse effects; MESH: HIV Integrase Inhibitors* / therapeutic use; MESH: Humans; MESH: Incidence; MESH: Male; MESH: Middle Aged; MESH: Retrospective Studies; MESH: Diabetes Mellitus* / epidemiology; MESH: Female; MESH: France / epidemiology; MESH: HIV Infections* / complications; [SDV.EE.SANT]Life Sciences [q-bio]/Ecology; environment/Health; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| Description: |
International audience ; Introduction: Prevention of cardiovascular disease is a major issue in the current management of people living with HIV. Concern is growing about the metabolic impact of integrase strand transfer inhibitors (INSTIs), which could lead to an increased risk of diabetes, but the data are conflicting. This is an updated version of our previous analysis, with longer follow-up and new molecules.Methods: We retrospectively evaluated the incidence of new-onset diabetes in people living with HIV starting combined antiretroviral therapy with an INSTI compared with non-nucleoside reverse transcriptase inhibitors and protease inhibitors. Data were collected from the Dat'AIDS cohort study, a collaboration of 30 HIV treatment centres in France. We used a propensity score-based inverse probability of treatment weighting approach to adjust for baseline characteristics between the two groups (INSTI and non-INSTI).Results: Between 2009 and 2021, a total of 12 150 people living with HIV were included. The incidence of diabetes was higher in the INSTI group than in the non-INSTI group (hazard ratio 1.38; 95% confidence interval 1.07-1.77; p = 0.012). Regardless of the third drug, but to a greater extent for INSTIs, we observed a peak of new-onset diabetes in the year following initiation of combined antiretroviral therapy.Conclusions: The incidence of diabetes was higher in people treated with integrase inhibitors than in those receiving other third agents. This increased risk occurred both during the first year of treatment and in the longer term. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39197859; PUBMED: 39197859; PUBMEDCENTRAL: PMC11725413 |
| DOI: |
10.1111/hiv.13698 |
| Availability: |
https://uca.hal.science/hal-05125019; https://uca.hal.science/hal-05125019v1/document; https://uca.hal.science/hal-05125019v1/file/Ursenbach_2024.pdf; https://doi.org/10.1111/hiv.13698 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.403D3B4 |
| Database: |
BASE |