Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish
| Title: | Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish |
|---|---|
| Authors: | Geudens, I; Herpers, Robert; Hermans, K; Segura, I; de Almodovar, CR; Bussmann, Hans; De Smet, F; Vandevelde, W; Hogan, BM; Siekmann, A; Claes, F; Moore, JC; Pistocchi, AS; Loges, S; Mazzone, M; Mariggi, G; Bruyere, F; Cotelli, F; Kerjaschki, D; Noel, A; Foidart, JM; Gerhardt, H; Ny, A; Langenberg, T; Lawson, ND; Duckers, Eric; Schulte-Merker, S; Carmeliet, P; Dewerchin, M |
| Source: | Geudens, I, Herpers, R, Hermans, K, Segura, I, de Almodovar, CR, Bussmann, H, De Smet, F, Vandevelde, W, Hogan, BM, Siekmann, A, Claes, F, Moore, JC, Pistocchi, AS, Loges, S, Mazzone, M, Mariggi, G, Bruyere, F, Cotelli, F, Kerjaschki, D, Noel, A, Foidart, JM, Gerhardt, H, Ny, A, Langenberg, T, Lawson, ND, Duckers, E, Schulte-Merker, S, Carmeliet, P & Dewerchin, M 2010, 'Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish', Arteriosclerosis Thrombosis & Vascular Biology, vol. 30, no. 9, pp. 1695-U60. https://doi.org/10.1161/ATVBAHA.110.203034 |
| Publication Year: | 2010 |
| Subject Terms: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCCOEUR09; name=EMC COEUR-09 |
| Description: | Objective-To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. Methods and Results-In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. Conclusion-These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network. (Arterioscler Thromb Vasc Biol. 2010; 30: 1695-1702.) |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| ISSN: | 1079-5642; 1524-4636 |
| Relation: | info:eu-repo/semantics/altIdentifier/pissn/1079-5642; info:eu-repo/semantics/altIdentifier/eissn/1524-4636 |
| DOI: | 10.1161/ATVBAHA.110.203034 |
| Availability: | https://pure.eur.nl/en/publications/2ba71a34-6428-4ee5-99c8-d019eea9328f; https://doi.org/10.1161/ATVBAHA.110.203034; https://hdl.handle.net/1765/20853 |
| Rights: | info:eu-repo/semantics/closedAccess |
| Accession Number: | edsbas.40589BE0 |
| Database: | BASE |