| Title: |
Development of Resistance to Ciprofloxacin, Rifampin, and Mupirocin in Methicillin-Susceptible and -Resistant Staphylococcus aureus Isolates |
| Authors: |
Schmitz, Franz-Josef; Fluit, Ad C.; Hafner, Dieter; Beeck, Andreas; Perdikouli, Mirella; Boos, Mechthild; Scheuring, Sybille; Verhoef, Jan; Köhrer, Karl; Von Eiff, Christof |
| Source: |
Antimicrobial Agents and Chemotherapy ; volume 44, issue 11, page 3229-3231 ; ISSN 0066-4804 1098-6596 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2000 |
| Description: |
A relationship between resistance to methicillin and resistance to fluoroquinolones, rifampin, and mupirocin has been described for Staphylococcus aureus . Differences in resistance rates may be explainable by a higher spontaneous mutation rate (MR) or a faster development of resistance (DIFF) in methicillin-resistant S. aureus (MRSA). No differences in MR, DIFF, and mutations in grlA and gyrA were detected between methicillin-susceptible S. aureus and MRSA. The higher resistance rates in MRSA are not the result of hypermutability of target genes or a faster emergence of different mutations and may be the consequence of clonal spread of multiresistant MRSA. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/aac.44.11.3229-3231.2000 |
| DOI: |
10.1128/AAC.44.11.3229-3231.2000 |
| Availability: |
https://doi.org/10.1128/aac.44.11.3229-3231.2000; https://journals.asm.org/doi/pdf/10.1128/AAC.44.11.3229-3231.2000 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.406AF9F0 |
| Database: |
BASE |