| Description: |
Background: The innate immune system (IIS) prevents the host from being infected by pathogenic organisms, including viruses, bacteria, parasites, and fungi. An increased metabolism level, which needs energy sources and substrates for strengthening and controlling molecules, supplemented this keen action, eventually obtained from the superfood. Aims: This is the first study that investigates the micronutrient values (MNVs) and microbial contents of an optimum blend formula at a ratio of 5:3:2 (grams) prepared for Acacia gums (Acacia seyal, Acacia sengal and Adansonia digitata L pulp (ADLPs)), respectively. Objective: The study's main objective is to develop an optimal formula using a specific combination of AGs and ADLPs to support the infected COVID-19 patient's IIS based on MNVs. Methods: We investigated the MNVs, including microbial content and vitamins, using High-Performance Liquid Chromatography (HPLC) and short-chain fatty acids (SCFA) from AGs, using an artificial stomach. We conducted a randomized trial and a pilot study to identify the effects of the daily optimum blended formula (OPF) (3 in 1) on Covid-19 patients. They gave one hundred five participants the blended (5:3:2 grams/3 times per day) until symptom relief. Results: Incubated at 35°C for 48 hours, the monocyte counts (MCs) of blended (3in1) revealed a safety level of less than 2.4x105 Cfu/g. Vitamins C, A, B1, and B3, which represented approximately 281±3.01, 201±1.53, 3.02±0.023, and 2±0.006 mg/100g DW, respectively, dominated the vitamin concentration of blended (3in1) significantly (p≤0.05) higher than all samples of vitamin content in this study. In terms of prebiotic activity, SCFA, such as acetate, butyrate, and propionate, AGs (PMC) produced (7% SCFA after 48 hours of incubation) significantly (p ≤ 0.05) less than AGs (PTC) (50% SCFA after 24 hours of incubation). Finally, based on biplot results, twenty-six (86%) out of the 30 patients improved dramatically over the three days in their clinical conditions on the symptoms, which . |