| Title: |
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation |
| Authors: |
Wu, Haibo; He, Peiqi; Ren, Yong; Xiao, Shiqi; Wang, Wei; Liu, Zhenbang; Li, Heng; Wang, Zhe; Zhang, Dingyu; Cai, Jun; Zhou, Xiangdong; Jiang, Dongpo; Fei, Xiaochun; Zhao, Lei; Zhang, Heng; Liu, Zhenhua; Chen, Rong; Li, Weiqing; Wang, Chaofu; Zhang, Shuyang; Qin, Jiwei; Nashan, Björn; Sun, Cheng |
| Contributors: |
National Natural Science Foundation of China; Natural Science Foundation of Anhui Province |
| Source: |
Nature Communications ; volume 13, issue 1 ; ISSN 2041-1723 |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2022 |
| Description: |
A complete diagnostic autopsy is the gold-standard to gain insight into Coronavirus disease 2019 (COVID-19) pathogenesis. To delineate the in situ immune responses to SARS-CoV-2 viral infection, here we perform comprehensive high-dimensional transcriptional and spatial immune profiling in 22 COVID-19 decedents from Wuhan, China. We find TIM-3-mediated and PD-1-mediated immunosuppression as a hallmark of severe COVID-19, particularly in men, with PD-1 + cells being proximal rather than distal to TIM-3 + cells. Concurrently, lymphocytes are distal, while activated myeloid cells are proximal, to SARS-CoV-2 viral antigens, consistent with prevalent SARS-CoV-2 infection of myeloid cells in multiple organs. Finally, viral load positively correlates with specific immunosuppression and dendritic cell markers. In summary, our data show that SARS-CoV-2 viral infection induces lymphocyte suppression yet myeloid activation in severe COVID-19, so these two cell types likely have distinct functions in severe COVID-19 disease progression, and should be targeted differently for therapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41467-021-27723-5 |
| Availability: |
https://doi.org/10.1038/s41467-021-27723-5; https://www.nature.com/articles/s41467-021-27723-5.pdf; https://www.nature.com/articles/s41467-021-27723-5 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.40E5358B |
| Database: |
BASE |