| Title: |
Pyridinium Alkynylanthracenes as Sensitizers for Photodynamic Therapy |
| Authors: |
Fudickar, Werner; Roder, Phillip; Listek, Martin; Hanack, Katja; Linker, Torsten |
| Contributors: |
Universität Potsdam |
| Source: |
Photochemistry and Photobiology ; volume 98, issue 1, page 193-201 ; ISSN 0031-8655 1751-1097 |
| Publisher Information: |
Wiley |
| Publication Year: |
2021 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Photodynamic therapy (PDT) is a mild but effective method to treat certain types of cancer upon irradiation with visible light. Here, three isomeric methylpyridinium alkynylanthracenes 1 o─p were evaluated as sensitizers for PDT. Upon irradiation with blue or green light, all three compounds show the ability to initiate strand breaks of plasmid DNA. The mayor species responsible for cleavage is singlet oxygen ( 1 O 2 ) as confirmed by scavenging reagents. Only isomers 1 m and 1 p can be incorporated into HeLa cells, whereas isomer 1 o cannot permeate through the membrane. While isomer 1 m targets the cell nucleus, isomer 1 p assembles in the cellular cytoplasm and impacts the cellular integrity. This is in accordance with a moderate toxicity of 1 p in the dark, whereas 1 m exhibits no dark toxicity. Both isomers are suitable as PDT reagents, with a CC 50 of 3 μ m and 75 n m , for 1 p and 1 m , respectively. Thus, derivative 1 m , which can be easily synthesized, becomes an interesting candidate for cancer therapy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/php.13554 |
| Availability: |
https://doi.org/10.1111/php.13554; https://onlinelibrary.wiley.com/doi/pdf/10.1111/php.13554; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/php.13554 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.410F45D9 |
| Database: |
BASE |