| Title: |
The development of a PET radiotracer for imaging alpha synuclein aggregates in Parkinson's disease |
| Authors: |
Tian, Gui-Long; Hsieh, Chia-Ju; Guarino, Dinahlee Saturnino; Graham, Thomas J. A.; Lengyel-Zhand, Zsofia; Schmitz, Alexander; Chia, Wai Kit; Young, Anthony J.; Crosby, John-Grey; Plakas, Konstantinos; Huang, Tianyu; Jiang, Hao; Yu, Yanbo; Hou, Catherine; Lee, Hsiaoju; Petersson, E. James; Giannakoulias, Sam; O'Shea, Jennifer; Kotzbauer, Paul; Tu, Zhude; Mathis, Chester A.; Mach, Robert H. |
| Contributors: |
National Institutes of Health |
| Source: |
RSC Medicinal Chemistry ; volume 16, issue 6, page 2743-2753 ; ISSN 2632-8682 |
| Publisher Information: |
Royal Society of Chemistry (RSC) |
| Publication Year: |
2025 |
| Description: |
An ultrahigh throughput in silico screen was conducted on 42 M compounds in the Mcule database and led to the identification of a new lead compound for radiotracer development for use with the imaging technique, positron emission tomography. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1039/d5md00057b |
| Availability: |
https://doi.org/10.1039/d5md00057b; http://pubs.rsc.org/en/content/articlepdf/2025/MD/D5MD00057B |
| Rights: |
http://creativecommons.org/licenses/by-nc/3.0/ |
| Accession Number: |
edsbas.41BE67AF |
| Database: |
BASE |